| Date | Name | Title | Type | Security | Shares | Price | Value | Ownership | Reported |
| 06/03/2016 | Devitt Blake E | Director | Disposition | | 32.9k | $0.00 | $0 | | 06/03/2016 |
| 06/03/2016 | Devitt Blake E | Director | Disposition | Stock Option (Right to Buy) | 4.3k | $26.33 | $112.7k | | 06/03/2016 |
| 06/03/2016 | Devitt Blake E | Director | Disposition | Stock Option (Right to Buy) | 3.8k | $28.95 | $108.9k | | 06/03/2016 |
| 06/03/2016 | Devitt Blake E | Director | Disposition | Stock Option (Right to Buy) | 5.7k | $22.95 | $130.4k | | 06/03/2016 |
| 06/03/2016 | Devitt Blake E | Director | Disposition | Stock Option (Right to Buy) | 4.3k | $20.81 | $89.9k | | 06/03/2016 |
| 06/03/2016 | Devitt Blake E | Director | Disposition | Stock Option (Right to Buy) | 5k | $26.80 | $133.7k | | 06/03/2016 |
| 06/03/2016 | Devitt Blake E | Director | Disposition | Stock Option (Right to Buy) | 4k | $25.30 | $101.7k | | 06/03/2016 |
| 06/03/2016 | Devitt Blake E | Director | Disposition | Stock Option (Right to Buy) | 3.9k | $31.65 | $124.4k | | 06/03/2016 |
| 06/03/2016 | Devitt Blake E | Director | Disposition | Stock Option (Right to Buy) | 4.1k | $34.14 | $140.3k | | 06/03/2016 |
| 06/03/2016 | Devitt Blake E | Director | Disposition | Stock Option (Right to Buy) | 12.6k | $32.15 | $404.7k | | 06/03/2016 |
| 06/03/2016 | Devitt Blake E | Director | Disposition | Stock Option (Right to Buy) | 293 | $31.50 | $9.2k | | 06/03/2016 |
| 06/03/2016 | HOMBACH ROBERT J. | EVP. CFO and COO | Grant | | 16.4k | $0.00 | $0 | | 06/03/2016 |
| 06/03/2016 | HOMBACH ROBERT J. | EVP. CFO and COO | Disposition | | 209.1k | $0.00 | $0 | | 06/03/2016 |
| 06/03/2016 | HOMBACH ROBERT J. | EVP. CFO and COO | Disposition | Stock Option (Right to Buy) | 49.6k | $24.83 | $1.2M | | 06/03/2016 |
| 06/03/2016 | HOMBACH ROBERT J. | EVP. CFO and COO | Disposition | Stock Option (Right to Buy) | 88.6k | $26.53 | $2.4M | | 06/03/2016 |
| 06/03/2016 | HOMBACH ROBERT J. | EVP. CFO and COO | Disposition | Stock Option (Right to Buy) | 95.2k | $32.42 | $3.1M | | 06/03/2016 |
| 06/03/2016 | HOMBACH ROBERT J. | EVP. CFO and COO | Disposition | Stock Option (Right to Buy) | 103.2k | $31.86 | $3.3M | | 06/03/2016 |
| 06/03/2016 | HOMBACH ROBERT J. | EVP. CFO and COO | Disposition | Stock Option (Right to Buy) | 287.9k | $32.04 | $9.2M | | 06/03/2016 |
| 06/03/2016 | HOMBACH ROBERT J. | EVP. CFO and COO | Disposition | Stock Option (Right to Buy) | 35.2k | $31.50 | $1.1M | | 06/03/2016 |
| 06/03/2016 | HOMBACH ROBERT J. | EVP. CFO and COO | Disposition | Stock Option (Right to Buy) | 380.5k | $31.50 | $12M | | 06/03/2016 |
| 06/03/2016 | Goff Brian | EVP and President, Hematology | Grant | | 2.9k | $0.00 | $0 | | 06/03/2016 |
| 06/03/2016 | Goff Brian | EVP and President, Hematology | Disposition | | 70k | $0.00 | $0 | | 06/03/2016 |
| 06/03/2016 | Goff Brian | EVP and President, Hematology | Disposition | Stock Option (Right to Buy) | 37k | $23.15 | $856.6k | | 06/03/2016 |
| 06/03/2016 | Goff Brian | EVP and President, Hematology | Disposition | Stock Option (Right to Buy) | 25.8k | $32.42 | $835.6k | | 06/03/2016 |
| 06/03/2016 | Goff Brian | EVP and President, Hematology | Disposition | Stock Option (Right to Buy) | 31.4k | $31.86 | $999.6k | | 06/03/2016 |
| 06/03/2016 | Goff Brian | EVP and President, Hematology | Disposition | Stock Option (Right to Buy) | 88.2k | $32.04 | $2.8M | | 06/03/2016 |
| 06/03/2016 | Goff Brian | EVP and President, Hematology | Disposition | Stock Option (Right to Buy) | 35.2k | $31.50 | $1.1M | | 06/03/2016 |
| 06/03/2016 | Goff Brian | EVP and President, Hematology | Disposition | Stock Option (Right to Buy) | 265.2k | $31.50 | $8.4M | | 06/03/2016 |
| 06/03/2016 | LEONARDI JACOPO | EVP and President, Immunology | Grant | | 1k | $0.00 | $0 | | 06/03/2016 |
| 06/03/2016 | LEONARDI JACOPO | EVP and President, Immunology | Disposition | | 56.4k | $0.00 | $0 | | 06/03/2016 |
| 06/03/2016 | LEONARDI JACOPO | EVP and President, Immunology | Disposition | | 1.1k | $0.00 | $0 | By 401(k) Plan | 06/03/2016 |
| 06/03/2016 | LEONARDI JACOPO | EVP and President, Immunology | Disposition | Stock Option (Right to Buy) | 2.1k | $26.53 | $54.4k | | 06/03/2016 |
| 06/03/2016 | LEONARDI JACOPO | EVP and President, Immunology | Disposition | Stock Option (Right to Buy) | 8.3k | $32.42 | $270k | | 06/03/2016 |
| 06/03/2016 | LEONARDI JACOPO | EVP and President, Immunology | Disposition | Stock Option (Right to Buy) | 11.3k | $31.86 | $358.8k | | 06/03/2016 |
| 06/03/2016 | LEONARDI JACOPO | EVP and President, Immunology | Disposition | Stock Option (Right to Buy) | 39.7k | $32.04 | $1.3M | | 06/03/2016 |
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