| Date | Name | Title | Type | Security | Shares | Price | Value | Ownership | Reported |
| 05/10/2023 | Kalb Michael Wayne | CFO | Grant | Stock Option (right to buy) | 175k | $2.43 | $425.2k | | 05/10/2023 |
| 05/10/2023 | Kalb Michael Wayne | CFO | Grant | Restricted Stock Units (RSUs) | 47.5k | $0.00 | $0 | | 05/10/2023 |
| 12/31/2022 | Leaman John Harold | Chief Fin. & Business Officer | Payment of Exercise | Common Stock | 3.6k | $3.75 | $13.6k | | 12/31/2022 |
| 12/31/2022 | Leaman John Harold | Chief Fin. & Business Officer | Exercise | Restricted Stock Units (RSUs) | 10.6k | $0.00 | $0 | | 12/31/2022 |
| 06/16/2022 | PARKER H STEWART | Director | Grant | Stock Option (right to buy) | 12.8k | $8.65 | $110.6k | | 06/16/2022 |
| 06/16/2022 | Wilfong Diane E. | Director | Grant | Stock Option (right to buy) | 12.8k | $8.65 | $110.6k | | 06/16/2022 |
| 06/16/2022 | NELSON TIMOTHY S | Director | Grant | Stock Option (right to buy) | 12.8k | $8.65 | $110.6k | | 06/16/2022 |
| 06/16/2022 | SHAH MAHENDRA | Director | Grant | Stock Option (right to buy) | 12.8k | $8.65 | $110.6k | | 06/16/2022 |
| 06/16/2022 | Allison David D. | Director | Grant | Stock Option (right to buy) | 12.8k | $8.65 | $110.6k | | 06/16/2022 |
| 03/29/2022 | SHREWSBURY STEPHEN B | Chief Medical Officer | Exercise | Stock Option (right to buy) | 24.6k | $1.97 | $48.5k | | 03/29/2022 |
| 01/26/2022 | SHREWSBURY STEPHEN B | Chief Medical Officer | Grant | Stock Option (right to buy) | 30k | $9.85 | $295.5k | | 01/26/2022 |
| 01/26/2022 | ADAMS ADRIAN | COB, CEO and President | Grant | Stock Option (right to buy) | 175k | $9.85 | $1.7M | | 01/26/2022 |
| 01/26/2022 | Leaman John Harold | Chief Fin. & Business Officer | Grant | Stock Option (right to buy) | 100k | $9.85 | $985k | | 01/26/2022 |
| 01/26/2022 | Paolillo Leonard | Chief Commercial Officer | Grant | Stock Option (right to buy) | 40k | $9.85 | $394k | | 01/26/2022 |
| 01/26/2022 | Hoekman John | Chief Scientific Officer | Grant | Stock Option (right to buy) | 35k | $9.85 | $344.8k | | 01/26/2022 |
| 12/22/2021 | Hoekman John | Chief Scientific Officer | Exercise | Stock Option (right to buy) | 20k | $1.64 | $32.8k | | 12/22/2021 |
| 11/19/2021 | NELSON TIMOTHY S | Director | Purchase | Common Stock | 10k | $10.76 | $107.6k | | 11/19/2021 |
| 10/19/2021 | Leaman John Harold | Chief Fin. & Business Officer | Grant | Restricted Stock Units (RSUs) | 10.6k | $0.00 | $0 | | 10/19/2021 |
| 09/21/2021 | SHREWSBURY STEPHEN B | Chief Medical Officer | Exercise | Stock Option (right to buy) | 14.8k | $1.97 | $29.1k | | 09/21/2021 |
| 09/21/2021 | SHREWSBURY STEPHEN B | Chief Medical Officer | Exercise | Stock Option (right to buy) | 4.6k | $2.46 | $11.4k | | 09/21/2021 |
| 09/21/2021 | SHREWSBURY STEPHEN B | Chief Medical Officer | Exercise | Stock Option (right to buy) | 54k | $2.95 | $159.2k | | 09/21/2021 |
| 07/11/2021 | NELSON TIMOTHY S | Director | Grant | Stock Option (right to buy) | 11.5k | $9.96 | $114.5k | | 07/11/2021 |
| 07/11/2021 | PARKER H STEWART | Director | Grant | Stock Option (right to buy) | 11.5k | $9.96 | $114.5k | | 07/11/2021 |
| 07/11/2021 | Allison David D. | Director | Grant | Stock Option (right to buy) | 11.5k | $9.96 | $114.5k | | 07/11/2021 |
| 07/11/2021 | Wilfong Diane E. | Director | Grant | Stock Option (right to buy) | 11.5k | $9.96 | $114.5k | | 07/11/2021 |
| 07/11/2021 | SHAH MAHENDRA | Director | Grant | Stock Option (right to buy) | 11.5k | $9.96 | $114.5k | | 07/11/2021 |
| 04/27/2021 | 5AM Ventures V, L.P. | 10% Owner | Conversion | Common Stock | 540.3k | $0.00 | $0 | See footnote | 04/27/2021 |
| 04/27/2021 | 5AM Ventures V, L.P. | 10% Owner | Conversion | Common Stock | 500.9k | $0.00 | $0 | See footnote | 04/27/2021 |
| 04/27/2021 | 5AM Ventures V, L.P. | 10% Owner | Conversion | Common Stock | 358.9k | $0.00 | $0 | See footnote | 04/27/2021 |
| 04/27/2021 | 5AM Ventures V, L.P. | 10% Owner | Conversion | Common Stock | 101.5k | $13.50 | $1.4M | See footnote | 04/27/2021 |
| 04/27/2021 | 5AM Ventures V, L.P. | 10% Owner | Purchase | Common Stock | 575k | $15.00 | $8.6M | See footnote | 04/27/2021 |
| 04/27/2021 | 5AM Ventures V, L.P. | 10% Owner | Conversion | Series C-1 Preferred Stock | 13.2M | $0.00 | $0 | See Footnote | 04/27/2021 |
| 04/27/2021 | 5AM Ventures V, L.P. | 10% Owner | Conversion | Series C-2 Preferred Stock | 8.8M | $0.00 | $0 | See Footnote | 04/27/2021 |
| 04/27/2021 | 5AM Ventures V, L.P. | 10% Owner | Conversion | Series C-3 Preferred Stock | 8.2M | $0.00 | $0 | See Footnote | 04/27/2021 |
| 04/27/2021 | 5AM Ventures V, L.P. | 10% Owner | Conversion | Series D Preferred Stock | 5.9M | $0.00 | $0 | See Footnote | 04/27/2021 |
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