ALPINE IMMUNE SCIENCES, INC. (NVLS) [Rocket]

Ownership

ALPINE IMMUNE SCIENCES, INC. (NVLS)

Portfolio as of:

Name	Shares	Change	Value	% Port	% OS	Hist	Date
RA CAPITAL MANAGEMENT, L.P.	4,691,178	293,810	48,225,310,000	0.91	9.78	Hist	06/30/2023
ORBIMED ADVISORS LLC	4,081,592	0	41,958,766,000	0.76	8.51	Hist	06/30/2023
GREAT POINT PARTNERS LLC	3,363,688	-274,030	34,578,713,000	6.77	7.01	Hist	06/30/2023
Frazier Life Sciences Management, L.P.	2,985,757	0	30,693,582,000	1.83	6.22	Hist	06/30/2023
Lynx1 Capital Management LP	2,670,472	-465,701	27,452,452,000	17.99	5.57	Hist	06/30/2023
Paradigm Biocapital Advisors LP	2,423,961	106,327	24,918,319,000	1.93	5.05	Hist	06/30/2023
BlackRock Inc.	2,281,692	728,772	23,455,795,000	0.00	4.76	Hist	06/30/2023
Omega Fund Management, LLC	2,029,580	0	20,864,082,000	11.69	4.23	Hist	06/30/2023
VANGUARD GROUP INC	1,403,967	281,167	14,432,781,000	0.00	2.93	Hist	06/30/2023
COMMODORE CAPITAL LP	1,325,000	0	13,621,000,000	1.53	2.76	Hist	06/30/2023
Avidity Partners Management LP	1,058,500	69,000	10,881,380,000	0.38	2.21	Hist	06/30/2023
Vivo Capital, LLC	914,913	914,913	9,405,306,000	0.65	1.91	Hist	06/30/2023
Octagon Capital Advisors LP	750,000	750,000	7,710,000,000	1.07	1.56	Hist	06/30/2023
FMR LLC	675,586	674,330	6,945,024,000	0.00	1.41	Hist	06/30/2023
GEODE CAPITAL MANAGEMENT, LLC	617,974	61,767	6,352,772,000	0.00	1.29	Hist	06/30/2023
STATE STREET CORP	572,842	269,424	5,888,816,000	0.00	1.19	Hist	06/30/2023
Ghost Tree Capital, LLC	347,432	147,432	3,571,601,000	1.18	0.72	Hist	06/30/2023
Tri Locum Partners LP	331,992	331,992	3,412,878,000	1.27	0.69	Hist	06/30/2023
NORTHERN TRUST CORP	257,524	63,537	2,647,347,000	0.00	0.54	Hist	06/30/2023
TCG Crossover Management, LLC	253,069	0	2,601,549,000	0.43	0.53	Hist	06/30/2023
Woodline Partners LP	237,564	237,564	2,442,158,000	0.03	0.50	Hist	06/30/2023
SPHERA FUNDS MANAGEMENT LTD.	200,000	0	2,056,000,000	0.32	0.42	Hist	06/30/2023
Walleye Capital LLC	164,673	130,556	1,692,838,000	0.01	0.34	Hist	06/30/2023
DIMENSIONAL FUND ADVISORS LP	141,499	1,827	1,454,631,000	0.00	0.29	Hist	06/30/2023
DEUTSCHE BANK AG\	127,325	112,574	1,308,901,000	0.00	0.27	Hist	06/30/2023
Affinity Asset Advisors, LLC	118,891	118,891	1,222,199,000			Hist	06/30/2023
MILLENNIUM MANAGEMENT LLC	116,175	116,175	1,194,279,000	0.00	0.24	Hist	06/30/2023
Nuveen Asset Management, LLC	93,677	61,948	962,999,000			Hist	06/30/2023
Bank of New York Mellon Corp	91,507	19,701	940,692,000	0.00	0.19	Hist	06/30/2023
HighVista Strategies LLC	90,287	0	928,150,000	0.42	0.19	Hist	06/30/2023
Soleus Capital Management, L.P.	88,073	88,073	905,390,000	0.10	0.18	Hist	06/30/2023
TWO SIGMA ADVISERS, LP	86,375	45,400	887,935,000	0.00	0.18	Hist	06/30/2023
TWO SIGMA INVESTMENTS, LP	58,028	58,028	596,528,000	0.00	0.12	Hist	06/30/2023
CITADEL ADVISORS LLC	53,723	32,519	552,272,000	0.00	0.11	Hist	06/30/2023
MORGAN STANLEY	50,204	32,643	516,097,000	0.00	0.10	Hist	06/30/2023
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