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PICTET ASSET MANAGEMENT LTD
> ALXN
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2021 | ALEXION PHARMACEUTICALS, INC. | ALXN | 982,218 | -966,132 | 180,443,000 | -123,967,000 | $183.71 |
| 12/31/2020 | ALEXION PHARMACEUTICALS, INC. | ALXN | 1,948,350 | 134,303 | 304,410,000 | 96,829,000 | $156.24 |
| 09/30/2020 | ALEXION PHARMACEUTICALS, INC. | ALXN | 1,814,047 | -77,280 | 207,581,000 | -4,702,000 | $114.43 |
| 06/30/2020 | ALEXION PHARMACEUTICALS, INC. | ALXN | 1,891,327 | 733,740 | 212,283,000 | 108,343,000 | $112.24 |
| 03/31/2020 | ALEXION PHARMACEUTICALS, INC. | ALXN | 1,157,587 | 328,356 | 103,940,000 | 14,259,000 | $89.79 |
| 12/31/2019 | ALEXION PHARMACEUTICALS, INC. | ALXN | 829,231 | -96,535 | 89,681,000 | -989,000 | $108.15 |
| 09/30/2019 | ALEXION PHARMACEUTICALS, INC. | ALXN | 925,766 | -674,260 | 90,670,000 | -118,901,000 | $97.94 |
| 06/30/2019 | ALEXION PHARMACEUTICALS, INC. | ALXN | 1,600,026 | -248,438 | 209,571,000 | -40,304,000 | $130.98 |
| 03/31/2019 | ALEXION PHARMACEUTICALS, INC. | ALXN | 1,848,464 | 127,040 | 249,875,000 | 82,277,000 | $135.18 |
| 12/31/2018 | ALEXION PHARMACEUTICALS, INC. | ALXN | 1,721,424 | 27,997 | 167,598,000 | -67,805,000 | $97.36 |
| 09/30/2018 | ALEXION PHARMACEUTICALS, INC. | ALXN | 1,693,427 | -6,414 | 235,403,000 | 24,368,000 | $139.01 |
| 06/30/2018 | ALEXION PHARMACEUTICALS, INC. | ALXN | 1,699,841 | 127,840 | 211,035,000 | 35,820,000 | $124.15 |
| 03/31/2018 | ALEXION PHARMACEUTICALS, INC. | ALXN | 1,572,001 | 251,811 | 175,215,000 | 17,333,000 | $111.46 |
| 12/31/2017 | ALEXION PHARMACEUTICALS, INC. | ALXN | 1,320,190 | 193,915 | 157,882,000 | -123,000 | $119.59 |
| 09/30/2017 | ALEXION PHARMACEUTICALS, INC. | ALXN | 1,126,275 | 323,409 | 158,005,000 | 60,665,000 | $140.29 |
| 03/31/2017 | ALEXION PHARMACEUTICALS, INC. | ALXN | 802,866 | 23,555 | 97,340,000 | 1,991,000 | $121.24 |
| 12/31/2016 | ALEXION PHARMACEUTICALS, INC. | ALXN | 779,311 | 39,303 | 95,349,000 | 4,668,000 | $122.35 |
| 09/30/2016 | ALEXION PHARMACEUTICALS, INC. | ALXN | 740,008 | 45,889 | 90,681,000 | -14,062,000 | $122.54 |
| 06/30/2016 | ALEXION PHARMACEUTICALS, INC. | ALXN | 694,119 | 694,119 | 104,743,000 | 104,743,000 | $150.90 |
| 03/31/2016 | ALEXION PHARMACEUTICALS, INC. | ALXN | 334,268 | 122,260 | 47,065,000 | 27,509,000 | $140.80 |
| 12/31/2015 | ALEXION PHARMACEUTICALS, INC. | ALXN | 333,989 | 121,981 | 63,708,000 | 44,152,000 | $190.75 |
| 09/30/2015 | ALEXION PHARMACEUTICALS, INC. | ALXN | 359,086 | 147,078 | 56,158,000 | 36,602,000 | $156.39 |
| 06/30/2015 | ALEXION PHARMACEUTICALS, INC. | ALXN | 351,251 | 139,243 | 69,351,000 | 49,795,000 | $197.44 |
| 03/31/2015 | ALEXION PHARMACEUTICALS, INC. | ALXN | 252,295 | 40,287 | 42,696,000 | 23,140,000 | $169.23 |
| 12/31/2014 | ALEXION PHARMACEUTICALS, INC. | ALXN | 230,114 | 18,106 | 42,578,000 | 23,022,000 | $185.03 |
| 09/30/2014 | ALEXION PHARMACEUTICALS, INC. | ALXN | 168,408 | -43,600 | 27,925,000 | 8,369,000 | $165.82 |
| 06/30/2014 | ALEXION PHARMACEUTICALS, INC. | ALXN | 186,608 | -25,400 | 29,158,000 | 9,602,000 | $156.25 |
| 03/31/2014 | ALEXION PHARMACEUTICALS, INC. | ALXN | 171,408 | -40,600 | 26,076,000 | 6,520,000 | $152.13 |
| 12/31/2013 | ALEXION PHARMACEUTICALS, INC. | ALXN | 172,708 | -39,300 | 22,981,000 | 3,425,000 | $133.06 |
| 09/30/2013 | ALEXION PHARMACEUTICALS, INC. | ALXN | 185,408 | -26,600 | 21,537,000 | 1,981,000 | $116.16 |
| 06/30/2013 | ALEXION PHARMACEUTICALS, INC. | ALXN | 212,008 | 212,008 | 19,556,000 | 19,556,000 | $92.24 |
| 12/31/2011 | ALEXION PHARMACEUTICALS, INC. | ALXN | 0 | -131,223 | 0 | -8,406,100 | |
| 09/30/2011 | ALEXION PHARMACEUTICALS, INC. | ALXN | 131,223 | 131,223 | 8,406,100 | 8,406,100 | $64.06 |
| 06/30/2011 | ALEXION PHARMACEUTICALS, INC. | ALXN | 0 | -15,351,109 | 0 | -1,514,847,436 | |
| 03/31/2011 | ALEXION PHARMACEUTICALS, INC. | ALXN | 15,351,109 | 15,351,109 | 1,514,847,436 | 1,514,847,436 | $98.68 |
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