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BAKER BROS. ADVISORS LP
> ALEC
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2023 | Alector, Inc. | ALEC | 964,851 | 282,860 | 5,798,755,000 | -496,022,000 | $6,010.00 |
| 12/31/2022 | Alector, Inc. | ALEC | 681,991 | 442,763 | 6,294,777,000 | 6,292,514,000 | $9,230.00 |
| 09/30/2022 | Alector, Inc. | ALEC | 239,228 | 0 | 2,263,000 | -168,000 | $9.46 |
| 06/30/2022 | Alector, Inc. | ALEC | 239,228 | 0 | 2,431,000 | -978,000 | $10.16 |
| 03/31/2022 | Alector, Inc. | ALEC | 239,228 | 0 | 3,409,000 | -1,531,000 | $14.25 |
| 12/31/2021 | Alector, Inc. | ALEC | 239,228 | 0 | 4,940,000 | -519,000 | $20.65 |
| 09/30/2021 | Alector, Inc. | ALEC | 239,228 | 0 | 5,459,000 | 476,000 | $22.82 |
| 06/30/2021 | Alector, Inc. | ALEC | 239,228 | 0 | 4,983,000 | 165,000 | $20.83 |
| 03/31/2021 | Alector, Inc. | ALEC | 239,228 | 0 | 4,818,000 | 1,198,000 | $20.14 |
| 12/31/2020 | Alector, Inc. | ALEC | 239,228 | -26,372 | 3,620,000 | 822,000 | $15.13 |
| 09/30/2020 | Alector, Inc. | ALEC | 265,600 | -14,400 | 2,798,000 | -4,045,000 | $10.53 |
| 06/30/2020 | Alector, Inc. | ALEC | 280,000 | 0 | 6,843,000 | 87,000 | $24.44 |
| 03/31/2020 | Alector, Inc. | ALEC | 280,000 | 280,000 | 6,756,000 | 6,756,000 | $24.13 |
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