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BAKER BROS. ADVISORS LP
> LPTX
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2023 | LEAP THERAPEUTICS, INC. | LPTX | 0 | -559,705 | 0 | -251,867,000 | |
| 12/31/2022 | LEAP THERAPEUTICS, INC. | LPTX | 559,705 | 0 | 251,867,000 | 251,374,000 | $450.00 |
| 09/30/2022 | LEAP THERAPEUTICS, INC. | LPTX | 559,705 | 0 | 493,000 | -151,000 | $0.88 |
| 06/30/2022 | LEAP THERAPEUTICS, INC. | LPTX | 559,705 | 0 | 644,000 | -335,000 | $1.15 |
| 03/31/2022 | LEAP THERAPEUTICS, INC. | LPTX | 559,705 | 0 | 979,000 | -834,000 | $1.75 |
| 12/31/2021 | LEAP THERAPEUTICS, INC. | LPTX | 559,705 | 0 | 1,813,000 | -431,000 | $3.24 |
| 09/30/2021 | LEAP THERAPEUTICS, INC. | LPTX | 559,705 | 0 | 2,244,000 | 1,326,000 | $4.01 |
| 06/30/2021 | LEAP THERAPEUTICS, INC. | LPTX | 559,705 | 0 | 918,000 | -145,000 | $1.64 |
| 03/31/2021 | LEAP THERAPEUTICS, INC. | LPTX | 559,705 | 0 | 1,063,000 | -196,000 | $1.90 |
| 12/31/2020 | LEAP THERAPEUTICS, INC. | LPTX | 559,705 | 0 | 1,259,000 | 151,000 | $2.25 |
| 09/30/2020 | LEAP THERAPEUTICS, INC. | LPTX | 559,705 | -418,749 | 1,108,000 | -937,000 | $1.98 |
| 06/30/2020 | LEAP THERAPEUTICS, INC. | LPTX | 978,454 | 0 | 2,045,000 | 499,000 | $2.09 |
| 03/31/2020 | LEAP THERAPEUTICS, INC. | LPTX | 978,454 | 0 | 1,546,000 | 450,000 | $1.58 |
| 12/31/2019 | LEAP THERAPEUTICS, INC. | LPTX | 978,454 | 0 | 1,096,000 | -49,000 | $1.12 |
| 09/30/2019 | LEAP THERAPEUTICS, INC. | LPTX | 978,454 | 978,454 | 1,145,000 | 1,145,000 | $1.17 |
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