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ROYAL BANK OF CANADA
> SBIO
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2023 | ALPS Medical Breakthroughs ETF | SBIO | 21,592 | -43,210 | 681,000,000 | -1,287,000,000 | $31,539.46 |
| 12/31/2022 | ALPS Medical Breakthroughs ETF | SBIO | 64,802 | 22,434 | 1,968,000,000 | 1,966,724,000 | $30,369.43 |
| 09/30/2022 | ALPS Medical Breakthroughs ETF | SBIO | 42,368 | -1,617 | 1,276,000 | 59,000 | $30.12 |
| 06/30/2022 | ALPS Medical Breakthroughs ETF | SBIO | 43,985 | 2,111 | 1,217,000 | -191,000 | $27.67 |
| 03/31/2022 | ALPS Medical Breakthroughs ETF | SBIO | 41,874 | 5,854 | 1,408,000 | -113,000 | $33.62 |
| 12/31/2021 | ALPS Medical Breakthroughs ETF | SBIO | 36,020 | -20,669 | 1,521,000 | -1,059,000 | $42.23 |
| 09/30/2021 | ALPS Medical Breakthroughs ETF | SBIO | 56,689 | -7,638 | 2,580,000 | -654,000 | $45.51 |
| 03/31/2021 | ALPS Medical Breakthroughs ETF | SBIO | 64,327 | 28,934 | 3,234,000 | 1,421,000 | $50.27 |
| 12/31/2020 | ALPS Medical Breakthroughs ETF | SBIO | 35,393 | -39,348 | 1,813,000 | -1,262,000 | $51.22 |
| 09/30/2020 | ALPS Medical Breakthroughs ETF | SBIO | 74,741 | 7,946 | 3,075,000 | 281,000 | $41.14 |
| 06/30/2020 | ALPS Medical Breakthroughs ETF | SBIO | 66,795 | 6,889 | 2,794,000 | 895,000 | $41.83 |
| 03/31/2020 | ALPS Medical Breakthroughs ETF | SBIO | 59,906 | 36,535 | 1,899,000 | 910,000 | $31.70 |
| 12/31/2019 | ALPS Medical Breakthroughs ETF | SBIO | 23,371 | -2,787 | 989,000 | 163,000 | $42.32 |
| 09/30/2019 | ALPS Medical Breakthroughs ETF | SBIO | 26,158 | 1,825 | 826,000 | -53,000 | $31.58 |
| 06/30/2019 | ALPS Medical Breakthroughs ETF | SBIO | 24,333 | -1,124 | 879,000 | -42,000 | $36.12 |
| 03/31/2019 | ALPS Medical Breakthroughs ETF | SBIO | 25,457 | -5,765 | 921,000 | 42,000 | $36.18 |
| 12/31/2018 | ALPS Medical Breakthroughs ETF | SBIO | 31,222 | 3,117 | 879,000 | -228,000 | $28.15 |
| 09/30/2018 | ALPS Medical Breakthroughs ETF | SBIO | 28,105 | 2,505 | 1,107,000 | 153,000 | $39.39 |
| 06/30/2018 | ALPS Medical Breakthroughs ETF | SBIO | 25,600 | -10,800 | 954,000 | -292,000 | $37.27 |
| 03/31/2018 | ALPS Medical Breakthroughs ETF | SBIO | 36,400 | 15,619 | 1,246,000 | 565,000 | $34.23 |
| 12/31/2017 | ALPS Medical Breakthroughs ETF | SBIO | 20,781 | -3,697 | 681,000 | -82,000 | $32.77 |
| 09/30/2017 | ALPS Medical Breakthroughs ETF | SBIO | 24,478 | 11,137 | 763,000 | 391,000 | $31.17 |
| 06/30/2017 | ALPS Medical Breakthroughs ETF | SBIO | 13,341 | -6,459 | 372,000 | -138,000 | $27.88 |
| 03/31/2017 | ALPS Medical Breakthroughs ETF | SBIO | 19,800 | 19,800 | 510,000 | 510,000 | $25.76 |
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