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MILLENNIUM MANAGEMENT LLC
> ZYNE
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2023 | Zynerba Pharmaceuticals, Inc. | ZYNE | 125,835 | -434,303 | 41,022,000 | 40,725,000 | $326.00 |
| 12/31/2022 | Zynerba Pharmaceuticals, Inc. | ZYNE | 560,138 | -37,462 | 297,000 | -140,000 | $0.53 |
| 09/30/2022 | Zynerba Pharmaceuticals, Inc. | ZYNE | 597,600 | 294,049 | 437,000 | 91,000 | $0.73 |
| 06/30/2022 | Zynerba Pharmaceuticals, Inc. | ZYNE | 303,551 | 303,551 | 346,000 | 346,000 | $1.14 |
| 12/31/2021 | Zynerba Pharmaceuticals, Inc. | ZYNE | 0 | -387,602 | 0 | -1,643,000 | |
| 09/30/2021 | Zynerba Pharmaceuticals, Inc. | ZYNE | 387,602 | -852 | 1,643,000 | -412,000 | $4.24 |
| 06/30/2021 | Zynerba Pharmaceuticals, Inc. | ZYNE | 388,454 | 366,074 | 2,055,000 | 1,951,000 | $5.29 |
| 03/31/2021 | Zynerba Pharmaceuticals, Inc. | ZYNE | 22,380 | 22,380 | 104,000 | 104,000 | $4.65 |
| 12/31/2020 | Zynerba Pharmaceuticals, Inc. | ZYNE | 0 | -214,803 | 0 | -724,000 | |
| 06/30/2020 | Zynerba Pharmaceuticals, Inc. | ZYNE | 214,803 | 214,803 | 724,000 | 724,000 | $3.37 |
| 12/31/2019 | Zynerba Pharmaceuticals, Inc. | ZYNE | 0 | -23,336 | 0 | -176,000 | |
| 09/30/2019 | Zynerba Pharmaceuticals, Inc. | ZYNE | 23,336 | 5,479 | 176,000 | -66,000 | $7.54 |
| 06/30/2019 | Zynerba Pharmaceuticals, Inc. | ZYNE | 17,857 | -2,853 | 242,000 | 130,000 | $13.55 |
| 03/31/2019 | Zynerba Pharmaceuticals, Inc. | ZYNE | 20,710 | -9,894 | 112,000 | 21,000 | $5.41 |
| 12/31/2018 | Zynerba Pharmaceuticals, Inc. | ZYNE | 30,604 | -123,299 | 91,000 | -1,165,000 | $2.97 |
| 09/30/2018 | Zynerba Pharmaceuticals, Inc. | ZYNE | 153,903 | -70,608 | 1,256,000 | -931,000 | $8.16 |
| 06/30/2018 | Zynerba Pharmaceuticals, Inc. | ZYNE | 224,511 | 120,570 | 2,187,000 | 1,284,000 | $9.74 |
| 03/31/2018 | Zynerba Pharmaceuticals, Inc. | ZYNE | 103,941 | 103,941 | 903,000 | 903,000 | $8.69 |
| 09/30/2017 | Zynerba Pharmaceuticals, Inc. | ZYNE | 0 | -16,772 | 0 | -285,000 | |
| 06/30/2017 | Zynerba Pharmaceuticals, Inc. | ZYNE | 16,772 | 16,772 | 285,000 | 285,000 | $16.99 |
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