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MILLENNIUM MANAGEMENT LLC
> IONS
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2023 | IONIS PHARMACEUTICALS INC | IONS | 418,913 | 303,407 | 17,188,000,000 | 17,183,637,000 | $41,030.00 |
| 12/31/2022 | IONIS PHARMACEUTICALS INC | IONS | 115,506 | 96,577 | 4,363,000 | 3,526,000 | $37.77 |
| 09/30/2022 | IONIS PHARMACEUTICALS INC | IONS | 18,929 | -301,686 | 837,000 | -11,032,000 | $44.22 |
| 06/30/2022 | IONIS PHARMACEUTICALS INC | IONS | 320,615 | 129,424 | 11,869,000 | 4,787,000 | $37.02 |
| 03/31/2022 | IONIS PHARMACEUTICALS INC | IONS | 191,191 | -1,431,947 | 7,082,000 | -42,310,000 | $37.04 |
| 12/31/2021 | IONIS PHARMACEUTICALS INC | IONS | 1,623,138 | 1,340,284 | 49,392,000 | 39,905,000 | $30.43 |
| 09/30/2021 | IONIS PHARMACEUTICALS INC | IONS | 282,854 | -512,988 | 9,487,000 | -22,259,000 | $33.54 |
| 06/30/2021 | IONIS PHARMACEUTICALS INC | IONS | 795,842 | 164,578 | 31,746,000 | 3,364,000 | $39.89 |
| 03/31/2021 | IONIS PHARMACEUTICALS INC | IONS | 631,264 | 100,675 | 28,382,000 | -1,618,000 | $44.96 |
| 12/31/2020 | IONIS PHARMACEUTICALS INC | IONS | 530,589 | 517,220 | 30,000,000 | 29,212,000 | $56.54 |
| 06/30/2020 | IONIS PHARMACEUTICALS INC | IONS | 13,369 | -58,223 | 788,000 | -2,597,000 | $58.94 |
| 03/31/2020 | IONIS PHARMACEUTICALS INC | IONS | 71,592 | 61,528 | 3,385,000 | 2,777,000 | $47.28 |
| 12/31/2019 | IONIS PHARMACEUTICALS INC | IONS | 10,064 | -45,141 | 608,000 | -2,699,000 | $60.41 |
| 09/30/2019 | IONIS PHARMACEUTICALS INC | IONS | 55,205 | -135,739 | 3,307,000 | -8,965,000 | $59.90 |
| 06/30/2019 | IONIS PHARMACEUTICALS INC | IONS | 190,944 | 25,905 | 12,272,000 | -1,124,000 | $64.27 |
| 03/31/2019 | IONIS PHARMACEUTICALS INC | IONS | 165,039 | 81,561 | 13,396,000 | 8,883,000 | $81.17 |
| 12/31/2018 | IONIS PHARMACEUTICALS INC | IONS | 83,478 | -44,849 | 4,513,000 | -2,106,000 | $54.06 |
| 09/30/2018 | IONIS PHARMACEUTICALS INC | IONS | 128,327 | -53,607 | 6,619,000 | -962,000 | $51.58 |
| 06/30/2018 | IONIS PHARMACEUTICALS INC | IONS | 181,934 | -90,903 | 7,581,000 | -4,446,000 | $41.67 |
| 03/31/2018 | IONIS PHARMACEUTICALS INC | IONS | 272,837 | 76,920 | 12,027,000 | 2,172,000 | $44.08 |
| 12/31/2017 | IONIS PHARMACEUTICALS INC | IONS | 195,917 | 2,874 | 9,855,000 | 68,000 | $50.30 |
| 09/30/2017 | IONIS PHARMACEUTICALS INC | IONS | 193,043 | 96,324 | 9,787,000 | 4,867,000 | $50.70 |
| 06/30/2017 | IONIS PHARMACEUTICALS INC | IONS | 96,719 | 96,719 | 4,920,000 | 4,920,000 | $50.87 |
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