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TIAA CREF INVESTMENT MANAGEMENT LLC
> MDCO
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 03/31/2019 | MEDICINES CO /DE | MDCO | 133,798 | -33,857 | 3,740,000 | 531,000 | $27.95 |
| 12/31/2018 | MEDICINES CO /DE | MDCO | 167,655 | 24,858 | 3,209,000 | -1,062,000 | $19.14 |
| 09/30/2018 | MEDICINES CO /DE | MDCO | 142,797 | -20,791 | 4,271,000 | -1,733,000 | $29.91 |
| 06/30/2018 | MEDICINES CO /DE | MDCO | 163,588 | -13,564 | 6,004,000 | 169,000 | $36.70 |
| 03/31/2018 | MEDICINES CO /DE | MDCO | 177,152 | -2,306 | 5,835,000 | 929,000 | $32.94 |
| 12/31/2017 | MEDICINES CO /DE | MDCO | 179,458 | -1,032 | 4,906,000 | -1,779,000 | $27.34 |
| 09/30/2017 | MEDICINES CO /DE | MDCO | 180,490 | -5,739 | 6,685,000 | -394,000 | $37.04 |
| 06/30/2017 | MEDICINES CO /DE | MDCO | 186,229 | -1,501 | 7,079,000 | -2,101,000 | $38.01 |
| 03/31/2017 | MEDICINES CO /DE | MDCO | 187,730 | -14,768 | 9,180,000 | 2,307,000 | $48.90 |
| 12/31/2016 | MEDICINES CO /DE | MDCO | 202,498 | -17,293 | 6,873,000 | -1,422,000 | $33.94 |
| 09/30/2016 | MEDICINES CO /DE | MDCO | 219,791 | -100,430 | 8,295,000 | -3,861,000 | $37.74 |
| 06/30/2016 | MEDICINES CO /DE | MDCO | 221,477 | -48,639 | 7,448,000 | -1,134,000 | $33.63 |
| 03/31/2016 | MEDICINES CO /DE | MDCO | 270,116 | -50,105 | 8,582,000 | -3,574,000 | $31.77 |
| 12/31/2015 | MEDICINES CO /DE | MDCO | 289,292 | -30,929 | 10,802,000 | -1,354,000 | $37.34 |
| 09/30/2015 | MEDICINES CO /DE | MDCO | 320,221 | 17,725 | 12,156,000 | 3,680,000 | $37.96 |
| 06/30/2015 | MEDICINES CO /DE | MDCO | 300,188 | -2,308 | 8,588,000 | 112,000 | $28.61 |
| 03/31/2015 | MEDICINES CO /DE | MDCO | 302,496 | -16,995 | 8,476,000 | 1,345,000 | $28.02 |
| 12/31/2014 | MEDICINES CO /DE | MDCO | 306,582 | -12,909 | 8,483,000 | 1,352,000 | $27.67 |
| 09/30/2014 | MEDICINES CO /DE | MDCO | 319,491 | -1,800 | 7,131,000 | -2,000,000 | $22.32 |
| 06/30/2014 | MEDICINES CO /DE | MDCO | 326,601 | 5,310 | 9,491,000 | 360,000 | $29.06 |
| 03/31/2014 | MEDICINES CO /DE | MDCO | 321,291 | 3,565 | 9,131,000 | -1,519,000 | $28.42 |
| 12/31/2013 | MEDICINES CO /DE | MDCO | 325,971 | 8,245 | 12,589,000 | 1,939,000 | $38.62 |
| 09/30/2013 | MEDICINES CO /DE | MDCO | 317,726 | 317,726 | 10,650,000 | 10,650,000 | $33.52 |
| 06/30/2013 | MEDICINES CO /DE | MDCO | 304,145 | 4,383 | 9,356,000 | 2,171,000 | $30.76 |
| 03/31/2013 | MEDICINES CO /DE | MDCO | 305,842 | 6,080 | 10,221,240 | 3,036,240 | $33.42 |
| 12/31/2012 | MEDICINES CO /DE | MDCO | 299,762 | 1,993 | 7,185,000 | -500,000 | $23.97 |
| 09/30/2012 | MEDICINES CO /DE | MDCO | 297,769 | -40,647 | 7,685,000 | -78,000 | $25.81 |
| 06/30/2012 | MEDICINES CO /DE | MDCO | 338,416 | -51,940 | 7,763,000 | -71,000 | $22.94 |
| 03/31/2012 | MEDICINES CO /DE | MDCO | 390,356 | -28,194 | 7,834,000 | 1,606,000 | $20.07 |
| 12/31/2011 | MEDICINES CO /DE | MDCO | 385,076 | -33,474 | 7,178,000 | 950,000 | $18.64 |
| 09/30/2011 | MEDICINES CO /DE | MDCO | 418,550 | -7,751 | 6,228,000 | -810,000 | $14.88 |
| 06/30/2011 | MEDICINES CO /DE | MDCO | 426,301 | -2,840 | 7,038,000 | 47,000 | $16.51 |
| 03/31/2011 | MEDICINES CO /DE | MDCO | 429,141 | 22,763 | 6,991,000 | 1,249,000 | $16.29 |
| 12/31/2010 | MEDICINES CO /DE | MDCO | 406,378 | 18,966 | 5,742,000 | 241,000 | $14.13 |
| 09/30/2010 | MEDICINES CO /DE | MDCO | 387,412 | -56,193 | 5,501,000 | 2,125,000 | $14.20 |
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