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JANE STREET GROUP, LLC
> AKBA
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2023 | Akebia Therapeutics, Inc. | AKBA | 57,111 | -466,592 | 52,257,000 | -249,919,000 | $915.01 |
| 12/31/2022 | Akebia Therapeutics, Inc. | AKBA | 523,703 | 513,064 | 302,176,000 | 302,173,000 | $577.00 |
| 09/30/2022 | Akebia Therapeutics, Inc. | AKBA | 10,639 | -151,527 | 3,000 | -54,000 | $0.28 |
| 06/30/2022 | Akebia Therapeutics, Inc. | AKBA | 162,166 | -388,481 | 57,000 | -338,000 | $0.35 |
| 03/31/2022 | Akebia Therapeutics, Inc. | AKBA | 550,647 | 263,945 | 395,000 | -253,000 | $0.72 |
| 12/31/2021 | Akebia Therapeutics, Inc. | AKBA | 286,702 | 210,403 | 648,000 | 359,000 | $2.26 |
| 06/30/2021 | Akebia Therapeutics, Inc. | AKBA | 76,299 | 43,740 | 289,000 | 179,000 | $3.79 |
| 03/31/2021 | Akebia Therapeutics, Inc. | AKBA | 32,559 | -44,083 | 110,000 | -105,000 | $3.38 |
| 12/31/2020 | Akebia Therapeutics, Inc. | AKBA | 76,642 | 39,729 | 215,000 | -286,000 | $2.81 |
| 06/30/2020 | Akebia Therapeutics, Inc. | AKBA | 36,913 | 21,390 | 501,000 | 383,000 | $13.57 |
| 03/31/2020 | Akebia Therapeutics, Inc. | AKBA | 15,523 | 4,280 | 118,000 | 47,000 | $7.60 |
| 12/31/2019 | Akebia Therapeutics, Inc. | AKBA | 11,243 | -20,953 | 71,000 | -55,000 | $6.32 |
| 09/30/2019 | Akebia Therapeutics, Inc. | AKBA | 32,196 | -84,991 | 126,000 | -441,000 | $3.91 |
| 06/30/2019 | Akebia Therapeutics, Inc. | AKBA | 117,187 | 117,187 | 567,000 | 567,000 | $4.84 |
| 03/31/2019 | Akebia Therapeutics, Inc. | AKBA | 0 | -10,268 | 0 | -57,000 | |
| 12/31/2018 | Akebia Therapeutics, Inc. | AKBA | 10,268 | 10,268 | 57,000 | 57,000 | $5.55 |
| 06/30/2018 | Akebia Therapeutics, Inc. | AKBA | 0 | -10,024 | 0 | -96,000 | |
| 03/31/2018 | Akebia Therapeutics, Inc. | AKBA | 10,024 | 10,024 | 96,000 | 96,000 | $9.58 |
| 09/30/2017 | Akebia Therapeutics, Inc. | AKBA | 0 | -26,186 | 0 | -376,000 | |
| 06/30/2017 | Akebia Therapeutics, Inc. | AKBA | 26,186 | 26,186 | 376,000 | 376,000 | $14.36 |
| 06/30/2016 | Akebia Therapeutics, Inc. | AKBA | 0 | -13,410 | 0 | -121,000 | |
| 03/31/2016 | Akebia Therapeutics, Inc. | AKBA | 13,410 | 13,410 | 121,000 | 121,000 | $9.02 |
| 09/30/2015 | Akebia Therapeutics, Inc. | AKBA | 0 | -12,915 | 0 | -133,000 | |
| 06/30/2015 | Akebia Therapeutics, Inc. | AKBA | 12,915 | 12,915 | 133,000 | 133,000 | $10.30 |
| 09/30/2014 | Akebia Therapeutics, Inc. | AKBA | 0 | -11,000 | 0 | -306,000 | |
| 06/30/2014 | Akebia Therapeutics, Inc. | AKBA | 11,000 | 11,000 | 306,000 | 306,000 | $27.82 |
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