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Rhenman & Partners Asset Management AB
> VRTX
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2023 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 63,500 | -32,500 | 22,346,285,000 | 22,316,333,000 | $351,910.00 |
| 09/30/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 96,000 | 1,000 | 29,952,000 | 3,182,000 | $312.00 |
| 06/30/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 95,000 | 5,500 | 26,770,000 | 3,413,000 | $281.79 |
| 03/31/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 89,500 | -75,500 | 23,357,000 | -13,347,000 | $260.97 |
| 12/31/2021 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 165,000 | 0 | 36,704,000 | 6,775,000 | $222.45 |
| 09/30/2021 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 165,000 | -50,897 | 29,929,000 | -13,602,000 | $181.39 |
| 06/30/2021 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 215,897 | 100,897 | 43,531,000 | 16,352,000 | $201.63 |
| 12/31/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 115,000 | 5,000 | 27,179,000 | -2,754,000 | $236.34 |
| 09/30/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 110,000 | -27,500 | 29,933,000 | -9,985,000 | $272.12 |
| 06/30/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 137,500 | 22,500 | 39,918,000 | 12,554,000 | $290.31 |
| 03/31/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 115,000 | -45,000 | 27,364,000 | -7,668,000 | $237.95 |
| 12/31/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 160,000 | -26,000 | 35,032,000 | 3,520,000 | $218.95 |
| 09/30/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 186,000 | 768 | 31,512,000 | -2,456,000 | $169.42 |
| 06/30/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 185,232 | 40,832 | 33,968,000 | 7,406,000 | $183.38 |
| 03/31/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 144,400 | 11,975 | 26,562,000 | 4,618,000 | $183.95 |
| 12/31/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 132,425 | -10,040 | 21,944,000 | -5,515,000 | $165.71 |
| 09/30/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 142,465 | -12,535 | 27,459,000 | 1,115,000 | $192.74 |
| 06/30/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 155,000 | 5,000 | 26,344,000 | 1,897,000 | $169.96 |
| 03/31/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 150,000 | -2,204 | 24,447,000 | 1,638,000 | $162.98 |
| 12/31/2017 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 152,204 | -27,796 | 22,809,000 | -4,558,000 | $149.86 |
| 09/30/2017 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 180,000 | 84,987 | 27,367,000 | 15,123,000 | $152.04 |
| 06/30/2017 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 95,013 | 0 | 12,244,000 | 1,854,000 | $128.87 |
| 03/31/2017 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 95,013 | 30,000 | 10,390,000 | 5,600,000 | $109.35 |
| 12/31/2016 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 65,013 | -15,000 | 4,790,000 | -6,973,144,000 | $73.68 |
| 09/30/2016 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 80,013 | 2,013 | 6,977,934,000 | 6,971,734,000 | $87,210.00 |
| 03/31/2016 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 78,000 | 22,000 | 6,200,000 | -846,000 | $79.49 |
| 12/31/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 56,000 | 56,000 | 7,046,000 | 7,046,000 | $125.82 |
| 09/30/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 105,000 | 50,000 | 10,935,000 | 4,144,000 | $104.14 |
| 06/30/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 55,000 | -3,000 | 6,791,000 | -51,000 | $123.47 |
| 03/31/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 58,000 | 58,000 | 6,842,000 | 6,842,000 | $117.97 |
| 12/31/2014 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 38,000 | 38,000 | 4,514,000 | 4,514,000 | $118.79 |
| 09/30/2014 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 43,000 | -58,600 | 4,829,000 | -4,790,000 | $112.30 |
| 06/30/2014 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 101,600 | 101,600 | 9,619,000 | 9,619,000 | $94.68 |
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