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Lombard Odier Asset Management (Switzerland) SA
> VRTX
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2023 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 57,844 | 10,359 | 20,355,882,000 | 5,394,783,000 | $351,910.00 |
| 03/31/2023 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 47,485 | 44,951 | 14,961,099,000 | 14,229,330,000 | $315,070.00 |
| 12/31/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 2,534 | 1,192 | 731,769,000 | 731,380,000 | $288,780.19 |
| 09/30/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,342 | -1,352 | 389,000 | -370,000 | $289.87 |
| 06/30/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 2,694 | 2,694 | 759,000 | 759,000 | $281.74 |
| 03/31/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 0 | -2,229 | 0 | -489,000 | |
| 12/31/2021 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 2,229 | 2,229 | 489,000 | 489,000 | $219.38 |
| 09/30/2021 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 0 | -1,395 | 0 | -281,000 | |
| 06/30/2021 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,395 | 1,395 | 281,000 | 281,000 | $201.43 |
| 12/31/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 0 | -978 | 0 | -266,000 | |
| 09/30/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 978 | 978 | 266,000 | 266,000 | $271.98 |
| 06/30/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 0 | -1,058 | 0 | -252,000 | |
| 03/31/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,058 | 0 | 252,000 | 20,000 | $238.19 |
| 12/31/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,058 | 1,058 | 232,000 | 232,000 | $219.28 |
| 06/30/2016 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 0 | -1,543 | 0 | -123,000 | |
| 03/31/2016 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,543 | 1,543 | 123,000 | 123,000 | $79.71 |
| 12/31/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,543 | 1,543 | 196,000 | 196,000 | $127.03 |
| 09/30/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 0 | -1,683 | 0 | -208,000 | |
| 06/30/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,683 | -93 | 208,000 | -4,000 | $123.59 |
| 03/31/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 2,580 | 804 | 305,000 | 93,000 | $118.22 |
| 12/31/2014 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,776 | 1,776 | 212,000 | 212,000 | $119.37 |
| 09/30/2014 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 23,918 | 23,918 | 2,700,000 | 2,700,000 | $112.89 |
| 06/30/2014 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 2,560 | 2,560 | 241,000 | 241,000 | $94.14 |
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