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ORBIMED ADVISORS LLC
> ALPN
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2023 | ALPINE IMMUNE SCIENCES, INC. | ALPN | 4,081,592 | 0 | 41,958,766,000 | 10,448,876,000 | $10,280.00 |
| 03/31/2023 | ALPINE IMMUNE SCIENCES, INC. | ALPN | 4,081,592 | 0 | 31,509,890,000 | 1,510,189,000 | $7,720.00 |
| 12/31/2022 | ALPINE IMMUNE SCIENCES, INC. | ALPN | 4,081,592 | 0 | 29,999,701,000 | 29,970,314,000 | $7,350.00 |
| 09/30/2022 | ALPINE IMMUNE SCIENCES, INC. | ALPN | 4,081,592 | 0 | 29,387,000 | -5,347,000 | $7.20 |
| 06/30/2022 | ALPINE IMMUNE SCIENCES, INC. | ALPN | 4,081,592 | 0 | 34,734,000 | -1,878,000 | $8.51 |
| 03/31/2022 | ALPINE IMMUNE SCIENCES, INC. | ALPN | 4,081,592 | 0 | 36,612,000 | -19,918,000 | $8.97 |
| 12/31/2021 | ALPINE IMMUNE SCIENCES, INC. | ALPN | 4,081,592 | 1,010,637 | 56,530,000 | 28,891,000 | $13.85 |
| 06/30/2021 | ALPINE IMMUNE SCIENCES, INC. | ALPN | 3,070,955 | 0 | 27,639,000 | -4,913,000 | $9.00 |
| 03/31/2021 | ALPINE IMMUNE SCIENCES, INC. | ALPN | 3,070,955 | 0 | 32,552,000 | -6,142,000 | $10.60 |
| 12/31/2020 | ALPINE IMMUNE SCIENCES, INC. | ALPN | 3,070,955 | -600,000 | 38,694,000 | 6,426,000 | $12.60 |
| 09/30/2020 | ALPINE IMMUNE SCIENCES, INC. | ALPN | 3,670,955 | 0 | 32,268,000 | -3,377,000 | $8.79 |
| 06/30/2020 | ALPINE IMMUNE SCIENCES, INC. | ALPN | 3,670,955 | 0 | 35,645,000 | 25,073,000 | $9.71 |
| 03/31/2020 | ALPINE IMMUNE SCIENCES, INC. | ALPN | 3,670,955 | 0 | 10,572,000 | -3,524,000 | $2.88 |
| 12/31/2019 | ALPINE IMMUNE SCIENCES, INC. | ALPN | 3,670,955 | 0 | 14,096,000 | -441,000 | $3.84 |
| 09/30/2019 | ALPINE IMMUNE SCIENCES, INC. | ALPN | 3,670,955 | 0 | 14,537,000 | -918,000 | $3.96 |
| 06/30/2019 | ALPINE IMMUNE SCIENCES, INC. | ALPN | 3,670,955 | 0 | 15,455,000 | -9,728,000 | $4.21 |
| 03/31/2019 | ALPINE IMMUNE SCIENCES, INC. | ALPN | 3,670,955 | 372,439 | 25,183,000 | 13,044,000 | $6.86 |
| 12/31/2018 | ALPINE IMMUNE SCIENCES, INC. | ALPN | 3,298,516 | 0 | 12,139,000 | -8,741,000 | $3.68 |
| 09/30/2018 | ALPINE IMMUNE SCIENCES, INC. | ALPN | 3,298,516 | 0 | 20,880,000 | -4,090,000 | $6.33 |
| 06/30/2018 | ALPINE IMMUNE SCIENCES, INC. | ALPN | 3,298,516 | 0 | 24,970,000 | -1,418,000 | $7.57 |
| 03/31/2018 | ALPINE IMMUNE SCIENCES, INC. | ALPN | 3,298,516 | 0 | 26,388,000 | -10,555,000 | $8.00 |
| 12/31/2017 | ALPINE IMMUNE SCIENCES, INC. | ALPN | 3,298,516 | 0 | 36,943,000 | -1,320,000 | $11.20 |
| 09/30/2017 | ALPINE IMMUNE SCIENCES, INC. | ALPN | 3,298,516 | 3,298,516 | 38,263,000 | 38,263,000 | $11.60 |
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