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ORBIMED ADVISORS LLC
> AGLE
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2023 | Aeglea BioTherapeutics, Inc. | AGLE | 0 | -1,797,221 | 0 | -521,194,000 | |
| 03/31/2023 | Aeglea BioTherapeutics, Inc. | AGLE | 1,797,221 | 0 | 521,194,000 | -287,376,000 | $290.00 |
| 12/31/2022 | Aeglea BioTherapeutics, Inc. | AGLE | 1,797,221 | 0 | 808,570,000 | 807,625,000 | $449.90 |
| 09/30/2022 | Aeglea BioTherapeutics, Inc. | AGLE | 1,797,221 | 0 | 945,000 | 37,000 | $0.53 |
| 06/30/2022 | Aeglea BioTherapeutics, Inc. | AGLE | 1,797,221 | -1,158,903 | 908,000 | -5,891,000 | $0.51 |
| 03/31/2022 | Aeglea BioTherapeutics, Inc. | AGLE | 2,956,124 | 0 | 6,799,000 | -7,243,000 | $2.30 |
| 12/31/2021 | Aeglea BioTherapeutics, Inc. | AGLE | 2,956,124 | -1,059,400 | 14,042,000 | -13,906,000 | $4.75 |
| 06/30/2021 | Aeglea BioTherapeutics, Inc. | AGLE | 4,015,524 | 0 | 27,948,000 | -3,855,000 | $6.96 |
| 03/31/2021 | Aeglea BioTherapeutics, Inc. | AGLE | 4,015,524 | 0 | 31,803,000 | 201,000 | $7.92 |
| 12/31/2020 | Aeglea BioTherapeutics, Inc. | AGLE | 4,015,524 | 0 | 31,602,000 | 3,132,000 | $7.87 |
| 09/30/2020 | Aeglea BioTherapeutics, Inc. | AGLE | 4,015,524 | 0 | 28,470,000 | -8,674,000 | $7.09 |
| 06/30/2020 | Aeglea BioTherapeutics, Inc. | AGLE | 4,015,524 | 1,150,000 | 37,144,000 | 23,791,000 | $9.25 |
| 03/31/2020 | Aeglea BioTherapeutics, Inc. | AGLE | 2,865,524 | 0 | 13,353,000 | -8,540,000 | $4.66 |
| 12/31/2019 | Aeglea BioTherapeutics, Inc. | AGLE | 2,865,524 | 0 | 21,893,000 | -143,000 | $7.64 |
| 09/30/2019 | Aeglea BioTherapeutics, Inc. | AGLE | 2,865,524 | 700,000 | 22,036,000 | 7,202,000 | $7.69 |
| 06/30/2019 | Aeglea BioTherapeutics, Inc. | AGLE | 2,165,524 | 0 | 14,834,000 | -2,598,000 | $6.85 |
| 03/31/2019 | Aeglea BioTherapeutics, Inc. | AGLE | 2,165,524 | 0 | 17,432,000 | 1,212,000 | $8.05 |
| 12/31/2018 | Aeglea BioTherapeutics, Inc. | AGLE | 2,165,524 | 0 | 16,220,000 | -4,504,000 | $7.49 |
| 09/30/2018 | Aeglea BioTherapeutics, Inc. | AGLE | 2,165,524 | 300,000 | 20,724,000 | 987,000 | $9.57 |
| 06/30/2018 | Aeglea BioTherapeutics, Inc. | AGLE | 1,865,524 | 396,000 | 19,737,000 | 5,159,000 | $10.58 |
| 03/31/2018 | Aeglea BioTherapeutics, Inc. | AGLE | 1,469,524 | 0 | 14,578,000 | 6,628,000 | $9.92 |
| 12/31/2017 | Aeglea BioTherapeutics, Inc. | AGLE | 1,469,524 | 0 | 7,950,000 | 706,000 | $5.41 |
| 09/30/2017 | Aeglea BioTherapeutics, Inc. | AGLE | 1,469,524 | 0 | 7,244,000 | 1,586,000 | $4.93 |
| 06/30/2017 | Aeglea BioTherapeutics, Inc. | AGLE | 1,469,524 | 0 | 5,658,000 | -5,290,000 | $3.85 |
| 03/31/2017 | Aeglea BioTherapeutics, Inc. | AGLE | 1,469,524 | 109,300 | 10,948,000 | 5,031,000 | $7.45 |
| 12/31/2016 | Aeglea BioTherapeutics, Inc. | AGLE | 1,360,224 | 0 | 5,917,000 | -2,802,000 | $4.35 |
| 09/30/2016 | Aeglea BioTherapeutics, Inc. | AGLE | 1,360,224 | 0 | 8,719,000 | 2,108,000 | $6.41 |
| 06/30/2016 | Aeglea BioTherapeutics, Inc. | AGLE | 1,360,224 | 1,360,224 | 6,611,000 | 6,611,000 | $4.86 |
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