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ORBIMED ADVISORS LLC
> IONS
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2023 | IONIS PHARMACEUTICALS INC | IONS | 2,169,500 | 45,000 | 89,014,585,000 | 13,084,955,000 | $41,030.00 |
| 03/31/2023 | IONIS PHARMACEUTICALS INC | IONS | 2,124,500 | 130,900 | 75,929,630,000 | 631,358,000 | $35,740.00 |
| 12/31/2022 | IONIS PHARMACEUTICALS INC | IONS | 1,993,600 | 1,224,700 | 75,298,272,000 | 75,264,264,000 | $37,770.00 |
| 09/30/2022 | IONIS PHARMACEUTICALS INC | IONS | 768,900 | 315,500 | 34,008,000 | 17,223,000 | $44.23 |
| 06/30/2022 | IONIS PHARMACEUTICALS INC | IONS | 453,400 | 453,400 | 16,785,000 | 16,785,000 | $37.02 |
| 03/31/2020 | IONIS PHARMACEUTICALS INC | IONS | 0 | -106,900 | 0 | -6,458,000 | |
| 12/31/2019 | IONIS PHARMACEUTICALS INC | IONS | 106,900 | 106,900 | 6,458,000 | 6,458,000 | $60.41 |
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