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ORBIMED ADVISORS LLC
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| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2023 | THERMO FISHER SCIENTIFIC INC. | TMO | 162,800 | 15,000 | 84,940,900,000 | -246,586,000 | $521,750.00 |
| 03/31/2023 | THERMO FISHER SCIENTIFIC INC. | TMO | 147,800 | -54,400 | 85,187,486,000 | -26,162,032,000 | $576,370.00 |
| 12/31/2022 | THERMO FISHER SCIENTIFIC INC. | TMO | 202,200 | 0 | 111,349,518,000 | 111,246,964,000 | $550,690.00 |
| 09/30/2022 | THERMO FISHER SCIENTIFIC INC. | TMO | 202,200 | 88,800 | 102,554,000 | 40,946,000 | $507.19 |
| 06/30/2022 | THERMO FISHER SCIENTIFIC INC. | TMO | 113,400 | -7,200 | 61,608,000 | -9,624,000 | $543.28 |
| 03/31/2022 | THERMO FISHER SCIENTIFIC INC. | TMO | 120,600 | 25,900 | 71,232,000 | 8,044,000 | $590.65 |
| 12/31/2021 | THERMO FISHER SCIENTIFIC INC. | TMO | 94,700 | -15,600 | 63,188,000 | 7,545,000 | $667.24 |
| 06/30/2021 | THERMO FISHER SCIENTIFIC INC. | TMO | 110,300 | 0 | 55,643,000 | 5,304,000 | $504.47 |
| 03/31/2021 | THERMO FISHER SCIENTIFIC INC. | TMO | 110,300 | 0 | 50,339,000 | -1,037,000 | $456.38 |
| 12/31/2020 | THERMO FISHER SCIENTIFIC INC. | TMO | 110,300 | 0 | 51,376,000 | 2,676,000 | $465.78 |
| 09/30/2020 | THERMO FISHER SCIENTIFIC INC. | TMO | 110,300 | 0 | 48,700,000 | 8,734,000 | $441.52 |
| 06/30/2020 | THERMO FISHER SCIENTIFIC INC. | TMO | 110,300 | 0 | 39,966,000 | 8,685,000 | $362.34 |
| 03/31/2020 | THERMO FISHER SCIENTIFIC INC. | TMO | 110,300 | -110,200 | 31,281,000 | -40,353,000 | $283.60 |
| 12/31/2019 | THERMO FISHER SCIENTIFIC INC. | TMO | 220,500 | -131,400 | 71,634,000 | -30,864,000 | $324.87 |
| 09/30/2019 | THERMO FISHER SCIENTIFIC INC. | TMO | 351,900 | -110,900 | 102,498,000 | -33,417,000 | $291.27 |
| 06/30/2019 | THERMO FISHER SCIENTIFIC INC. | TMO | 462,800 | 15,500 | 135,915,000 | 13,480,000 | $293.68 |
| 03/31/2019 | THERMO FISHER SCIENTIFIC INC. | TMO | 447,300 | 9,800 | 122,435,000 | 24,527,000 | $273.72 |
| 12/31/2018 | THERMO FISHER SCIENTIFIC INC. | TMO | 437,500 | -230,500 | 97,908,000 | -65,137,000 | $223.79 |
| 09/30/2018 | THERMO FISHER SCIENTIFIC INC. | TMO | 668,000 | 84,500 | 163,045,000 | 42,179,000 | $244.08 |
| 06/30/2018 | THERMO FISHER SCIENTIFIC INC. | TMO | 583,500 | 194,100 | 120,866,000 | 40,470,000 | $207.14 |
| 03/31/2018 | THERMO FISHER SCIENTIFIC INC. | TMO | 389,400 | 0 | 80,396,000 | 6,457,000 | $206.46 |
| 12/31/2017 | THERMO FISHER SCIENTIFIC INC. | TMO | 389,400 | -144,800 | 73,939,000 | -27,132,000 | $189.88 |
| 09/30/2017 | THERMO FISHER SCIENTIFIC INC. | TMO | 534,200 | 0 | 101,071,000 | 7,869,000 | $189.20 |
| 06/30/2017 | THERMO FISHER SCIENTIFIC INC. | TMO | 534,200 | 0 | 93,202,000 | 11,149,000 | $174.47 |
| 03/31/2017 | THERMO FISHER SCIENTIFIC INC. | TMO | 534,200 | -265,300 | 82,053,000 | -30,756,000 | $153.60 |
| 12/31/2016 | THERMO FISHER SCIENTIFIC INC. | TMO | 799,500 | -17,000 | 112,809,000 | -17,063,000 | $141.10 |
| 09/30/2016 | THERMO FISHER SCIENTIFIC INC. | TMO | 816,500 | -560,700 | 129,872,000 | -73,623,000 | $159.06 |
| 06/30/2016 | THERMO FISHER SCIENTIFIC INC. | TMO | 1,377,200 | 1,377,200 | 203,495,000 | 203,495,000 | $147.76 |
| 03/31/2016 | THERMO FISHER SCIENTIFIC INC. | TMO | 1,435,000 | 55,000 | 203,182,000 | 7,429,000 | $141.59 |
| 12/31/2015 | THERMO FISHER SCIENTIFIC INC. | TMO | 1,380,000 | 382,000 | 195,753,000 | 132,101,000 | $141.85 |
| 09/30/2015 | THERMO FISHER SCIENTIFIC INC. | TMO | 1,364,000 | 366,000 | 166,790,000 | 103,138,000 | $122.28 |
| 06/30/2015 | THERMO FISHER SCIENTIFIC INC. | TMO | 0 | -998,000 | 0 | -63,652,000 | |
| 03/31/2015 | THERMO FISHER SCIENTIFIC INC. | TMO | 1,811,700 | 813,700 | 243,384,000 | 179,732,000 | $134.34 |
| 12/31/2014 | THERMO FISHER SCIENTIFIC INC. | TMO | 1,595,700 | 597,700 | 199,925,000 | 136,273,000 | $125.29 |
| 09/30/2014 | THERMO FISHER SCIENTIFIC INC. | TMO | 1,691,400 | 693,400 | 205,843,000 | 142,191,000 | $121.70 |
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