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INTERNATIONAL BIOTECHNOLOGY TRUST PLC
> AGIO
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2023 | AGIOS PHARMACEUTICALS, INC. | AGIO | 24,000 | 24,000 | 679,680,000 | 679,680,000 | $28,320.00 |
| 09/30/2022 | AGIOS PHARMACEUTICALS, INC. | AGIO | 0 | -476 | 0 | -21,500,000 | |
| 06/30/2022 | AGIOS PHARMACEUTICALS, INC. | AGIO | 476 | -21,024 | 21,500,000 | 20,793,000 | $45,168.07 |
| 03/31/2022 | AGIOS PHARMACEUTICALS, INC. | AGIO | 21,500 | 0 | 707,000 | 0 | $32.88 |
| 12/31/2021 | AGIOS PHARMACEUTICALS, INC. | AGIO | 21,500 | 0 | 707,000 | -285,000 | $32.88 |
| 09/30/2021 | AGIOS PHARMACEUTICALS, INC. | AGIO | 21,500 | 0 | 992,000 | -116,000 | $46.14 |
| 03/31/2021 | AGIOS PHARMACEUTICALS, INC. | AGIO | 21,500 | 0 | 1,108,000 | 176,000 | $51.53 |
| 12/31/2020 | AGIOS PHARMACEUTICALS, INC. | AGIO | 21,500 | 0 | 932,000 | 180,000 | $43.35 |
| 09/30/2020 | AGIOS PHARMACEUTICALS, INC. | AGIO | 21,500 | 0 | 752,000 | -387,000 | $34.98 |
| 06/30/2020 | AGIOS PHARMACEUTICALS, INC. | AGIO | 21,500 | 0 | 1,139,000 | 377,000 | $52.98 |
| 03/31/2020 | AGIOS PHARMACEUTICALS, INC. | AGIO | 21,500 | -15,000 | 762,000 | -418,000 | $35.44 |
| 12/31/2019 | AGIOS PHARMACEUTICALS, INC. | AGIO | 36,500 | 0 | 1,743,000 | 563,000 | $47.75 |
| 09/30/2019 | AGIOS PHARMACEUTICALS, INC. | AGIO | 36,500 | 0 | 1,180,000 | -641,000 | $32.33 |
| 06/30/2019 | AGIOS PHARMACEUTICALS, INC. | AGIO | 36,500 | 0 | 1,821,000 | -641,000 | $49.89 |
| 03/31/2019 | AGIOS PHARMACEUTICALS, INC. | AGIO | 36,500 | 0 | 2,462,000 | 1,141,000 | $67.45 |
| 12/31/2018 | AGIOS PHARMACEUTICALS, INC. | AGIO | 36,500 | 0 | 1,321,000 | -838,000 | $36.19 |
| 09/30/2018 | AGIOS PHARMACEUTICALS, INC. | AGIO | 36,500 | 0 | 2,159,000 | -915,000 | $59.15 |
| 06/30/2018 | AGIOS PHARMACEUTICALS, INC. | AGIO | 36,500 | 0 | 3,074,000 | 89,000 | $84.22 |
| 03/31/2018 | AGIOS PHARMACEUTICALS, INC. | AGIO | 36,500 | 16,500 | 2,985,000 | 1,842,000 | $81.78 |
| 12/31/2017 | AGIOS PHARMACEUTICALS, INC. | AGIO | 20,000 | -17,000 | 1,143,000 | -761,000 | $57.15 |
| 09/30/2017 | AGIOS PHARMACEUTICALS, INC. | AGIO | 20,000 | -17,000 | 1,334,000 | -570,000 | $66.70 |
| 06/30/2017 | AGIOS PHARMACEUTICALS, INC. | AGIO | 37,000 | 17,000 | 1,904,000 | 736,000 | $51.46 |
| 03/31/2017 | AGIOS PHARMACEUTICALS, INC. | AGIO | 20,000 | 20,000 | 1,168,000 | 1,168,000 | $58.40 |
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