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SPHERA FUNDS MANAGEMENT LTD.
> ALPN
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2023 | ALPINE IMMUNE SCIENCES, INC. | ALPN | 200,000 | 0 | 2,056,000,000 | 586,000,000 | $10,280.00 |
| 12/31/2022 | ALPINE IMMUNE SCIENCES, INC. | ALPN | 200,000 | 0 | 1,470,000,000 | 1,468,560,000 | $7,350.00 |
| 09/30/2022 | ALPINE IMMUNE SCIENCES, INC. | ALPN | 200,000 | 200,000 | 1,440,000 | 1,440,000 | $7.20 |
| 06/30/2021 | ALPINE IMMUNE SCIENCES, INC. | ALPN | 0 | -198,260 | 0 | -2,498,000 | |
| 12/31/2020 | ALPINE IMMUNE SCIENCES, INC. | ALPN | 198,260 | 0 | 2,498,000 | 755,000 | $12.60 |
| 09/30/2020 | ALPINE IMMUNE SCIENCES, INC. | ALPN | 198,260 | 198,260 | 1,743,000 | 1,743,000 | $8.79 |
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