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MARSHALL WACE, LLP
> SAGE
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2023 | Sage Therapeutics, Inc. | SAGE | 798,548 | -134,375 | 37,547,725,000 | 1,966,042,000 | $47,020.00 |
| 12/31/2022 | Sage Therapeutics, Inc. | SAGE | 932,923 | -69,737 | 35,581,683,000 | 35,542,419,000 | $38,140.00 |
| 09/30/2022 | Sage Therapeutics, Inc. | SAGE | 1,002,660 | -612,646 | 39,264,000 | -12,911,000 | $39.16 |
| 06/30/2022 | Sage Therapeutics, Inc. | SAGE | 1,615,306 | 981,273 | 52,175,000 | 31,189,000 | $32.30 |
| 03/31/2022 | Sage Therapeutics, Inc. | SAGE | 634,033 | 599,646 | 20,986,000 | 19,523,000 | $33.10 |
| 12/31/2021 | Sage Therapeutics, Inc. | SAGE | 34,387 | -44,834 | 1,463,000 | -2,047,000 | $42.55 |
| 09/30/2021 | Sage Therapeutics, Inc. | SAGE | 79,221 | 79,221 | 3,510,000 | 3,510,000 | $44.31 |
| 03/31/2021 | Sage Therapeutics, Inc. | SAGE | 0 | -4,156 | 0 | -360,000 | |
| 12/31/2020 | Sage Therapeutics, Inc. | SAGE | 4,156 | -7,671 | 360,000 | -363,000 | $86.62 |
| 09/30/2020 | Sage Therapeutics, Inc. | SAGE | 11,827 | 11,827 | 723,000 | 723,000 | $61.13 |
| 06/30/2020 | Sage Therapeutics, Inc. | SAGE | 0 | -26,651 | 0 | -765,000 | |
| 03/31/2020 | Sage Therapeutics, Inc. | SAGE | 26,651 | 17,515 | 765,000 | 105,000 | $28.70 |
| 12/31/2019 | Sage Therapeutics, Inc. | SAGE | 9,136 | 6,834 | 660,000 | 337,000 | $72.24 |
| 09/30/2019 | Sage Therapeutics, Inc. | SAGE | 2,302 | -2,994 | 323,000 | -647,000 | $140.31 |
| 06/30/2019 | Sage Therapeutics, Inc. | SAGE | 5,296 | -17,549 | 970,000 | -2,663,000 | $183.16 |
| 03/31/2019 | Sage Therapeutics, Inc. | SAGE | 22,845 | -51,703 | 3,633,000 | -3,508,000 | $159.03 |
| 12/31/2018 | Sage Therapeutics, Inc. | SAGE | 74,548 | 7,372 | 7,141,000 | -2,348,000 | $95.79 |
| 09/30/2018 | Sage Therapeutics, Inc. | SAGE | 67,176 | -22,814 | 9,489,000 | -4,597,000 | $141.26 |
| 06/30/2018 | Sage Therapeutics, Inc. | SAGE | 89,990 | -101,407 | 14,086,000 | -16,742,000 | $156.53 |
| 03/31/2018 | Sage Therapeutics, Inc. | SAGE | 191,397 | 56,609 | 30,828,000 | 8,627,000 | $161.07 |
| 12/31/2017 | Sage Therapeutics, Inc. | SAGE | 134,788 | 134,788 | 22,201,000 | 22,201,000 | $164.71 |
| 06/30/2017 | Sage Therapeutics, Inc. | SAGE | 0 | -20,108 | 0 | -1,428,000 | |
| 03/31/2017 | Sage Therapeutics, Inc. | SAGE | 20,108 | -289,979 | 1,428,000 | -14,405,000 | $71.02 |
| 12/31/2016 | Sage Therapeutics, Inc. | SAGE | 310,087 | -363,452 | 15,833,000 | -15,184,000 | $51.06 |
| 09/30/2016 | Sage Therapeutics, Inc. | SAGE | 673,539 | -17,426 | 31,017,000 | 10,199,000 | $46.05 |
| 06/30/2016 | Sage Therapeutics, Inc. | SAGE | 690,965 | 631,743 | 20,818,000 | 18,919,000 | $30.13 |
| 03/31/2016 | Sage Therapeutics, Inc. | SAGE | 59,222 | 59,222 | 1,899,000 | 1,899,000 | $32.07 |
| 12/31/2015 | Sage Therapeutics, Inc. | SAGE | 32,074 | 32,074 | 1,870,000 | 1,870,000 | $58.30 |
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