Type	Name	Date
Indenture	Indenture, by and between the Company and U.S. Bank Trust Company, National Association, as Trustee	06/12/2023
Indenture	Indenture, by and between the Company and U.S. Bank National Association, as Trustee	04/13/2021
Indenture	Indenture, by and between Ionis Pharmaceuticals, Inc. and U.S. Bank National Association, as trustee	12/23/2019
Underwriting agreement	Underwriting Agreement	05/09/2013
Indenture	Indenture by and between Isis Pharmaceuticals, Inc. and Wells Fargo Bank, National Association, as trustee	08/13/2012

Type	Name	Date
By-Laws	Amended and Restated Bylaws	03/29/2021
By-Laws	Amended and Restated Bylaws of Isis Pharmaceuticals, Inc	12/14/2011

Type	Name	Date
Merger agreement	Agreement and Plan of Merger, among Akcea Therapeutics, Inc., Ionis Pharmaceuticals, Inc. and Avalanche Merger Sub, Inc	08/31/2020