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Security holder agreements
| Type | Name | Date |
| Underwriting agreement | Underwriting Agreement, by and among the Company and Morgan Stanley & Co. LLC, Jefferies, LLC and Leerink Partners LLC, as representatives of the several Underwriters | 09/14/2017 |
| Underwriting agreement | Underwriting Agreement, by and among the Company and Citigroup Global Markets Inc., Leerink Partners LLC and RBC Capital Markets, LLC, as representatives of the several Underwriters | 01/07/2016 |
| Underwriting agreement | Underwriting Agreement, by and among the Company and Leerink Partners LLC and Cowen and Company, LLC, as representatives of the several Underwriters | 03/18/2015 |
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