Type	Name	Date
Credit agreement	Amendment No. 9, to the Credit Agreement, by and among Horizon Therapeutics USA, Inc., as borrower, Horizon Therapeutics plc, as Irish Holdco and a guarantor, the subsidiary guarantors party thereto, as subsidiary guarantors, the lenders party thereto and Citibank, N.A., as administrative agent and collateral agent	03/15/2021
Indenture	Indenture by and between Horizon Pharma USA, Inc., the guarantors party thereto and U.S. Bank National Association, as trustee	07/16/2019
Indenture	Indenture by and between Horizon Pharma USA, Inc., the guarantors party thereto and U.S. Bank National Association, as trustee	07/16/2019
Indenture	Indenture by and between Horizon Pharma, Inc., Horizon Pharma USA, Inc. and U.S. Bank National Association, as trustee	10/25/2016
Credit agreement	Amendment No. 1, to Credit Agreement, by and among Horizon Pharma, Inc., as borrower, Horizon Pharma Public Limited Company, as Irish Holdco and a guarantor, the subsidiary guarantors party thereto, as subsidiary guarantors, the lenders party thereto and Citibank, N.A., as administrative agent and collateral agent	10/25/2016
Indenture	First Supplemental Indenture, among the Company, HPI, the Subsidiary Guarantors and U.S. Bank National Association, as trustee	05/11/2015
Credit agreement	Credit Agreement, among the Company, HPI, the subsidiary guarantors party thereto, the lenders party thereto and Citibank, N.A., as Administrative Agent and Collateral Agent	05/11/2015
Indenture	Indenture by and between Horizon Pharma Public Limited Company, Horizon Pharma Investment Limited and U.S. Bank National Association, as trustee	04/29/2015
Indenture	Indenture by and between Horizon Pharma Public Limited Company, Horizon Pharma Investment Limited and U.S. Bank National Association, as trustee	03/13/2015
Indenture	First Supplemental Indenture, by and among Horizon Pharma, Inc., Horizon Pharma Public Limited Company and U.S Bank National Association	09/19/2014
Credit agreement	Credit Agreement, by and among Horizon Pharma, Inc., as initial signatory, the lenders party thereto and Citibank, N.A., as administrative agent and collateral agent	06/19/2014
Indenture	Indenture, by and between Horizon Pharma, Inc. and U.S. Bank National Association	11/25/2013
Underwriting agreement	Underwriting Agreement	09/20/2012
Securities purchase agreement	Securities Purchase Agreement, by and among Horizon and the purchasers and warrant holders listed in Exhibits A and B thereto	03/01/2012

Type	Name	Date
By-Laws	Amended and Restated Bylaws of Horizon Pharma, Inc	08/02/2011

Type	Name	Date
Equity incentive plans	Horizon Therapeutics Public Limited Company 2020 Equity Incentive Plan	05/01/2020
Equity incentive plans	Horizon Pharma Public Limited Company 2014 Equity Incentive Plan, as amended	01/11/2018

Type	Name	Date
Merger agreement	Agreement and Plan of Merger, by and among Horizon Pharma plc, Misneach Corporation and Raptor Pharmaceutical Corp	09/12/2016
Merger agreement	Agreement and Plan of Merger, by and among Horizon Pharma, Inc., Ghrian Acquisition Inc. and Hyperion Therapeutics, Inc	04/09/2015
Merger agreement	Agreement and Plan of Merger, by and among Horizon Pharma, Inc., Ghrian Acquisition Inc. and Hyperion Therapeutics, Inc	03/31/2015