| Date | Name | Title | Type | Security | Shares | Price | Value | Ownership | Reported |
| 07/17/2023 | Fry Hannah | VP, Controller | Payment of Exercise | Common Stock | 10.1k | $2.56 | $25.8k | | 07/17/2023 |
| 07/03/2023 | Bandari Jathin | Chief Medical Officer | Payment of Exercise | Common Stock | 682 | $2.46 | $1.7k | | 07/03/2023 |
| 06/07/2023 | BESHAR LUKE M | Director | Grant | Stock Option (Right to Buy) | 10k | $2.85 | $28.5k | | 06/07/2023 |
| 06/07/2023 | Smith Cynthia | Director | Grant | Stock Option (Right to Buy) | 10k | $2.85 | $28.5k | | 06/07/2023 |
| 06/07/2023 | Huang Jane | Director | Grant | Stock Option (Right to Buy) | 10k | $2.85 | $28.5k | | 06/07/2023 |
| 06/07/2023 | Solomon Michael Edward | Director | Grant | Stock Option (Right to Buy) | 10k | $2.85 | $28.5k | | 06/07/2023 |
| 06/07/2023 | GARCEAU ROGER | Director | Grant | Stock Option (Right to Buy) | 10k | $2.85 | $28.5k | | 06/07/2023 |
| 06/07/2023 | Flannelly Barry P | Director | Grant | Stock Option (Right to Buy) | 10k | $2.85 | $28.5k | | 06/07/2023 |
| 06/07/2023 | SARGEN GREGORY | Director | Grant | Stock Option (Right to Buy) | 10k | $2.85 | $28.5k | | 06/07/2023 |
| 06/07/2023 | Levy Richard S | Director | Grant | Stock Option (Right to Buy) | 10k | $2.85 | $28.5k | | 06/07/2023 |
| 01/30/2023 | Fabbio Patrick | CFO | Grant | Stock Option (Right to Buy) | 300k | $3.14 | $942k | | 01/30/2023 |
| 01/19/2023 | Fry Hannah | VP, Controller | Grant | Common Stock | 5.9k | $0.00 | $0 | | 01/19/2023 |
| 01/19/2023 | Fry Hannah | VP, Controller | Grant | Stock Option (Right to Buy) | 35.4k | $3.02 | $106.9k | | 01/19/2023 |
| 01/19/2023 | Zummo Jacqueline | Chf Scientific Operations Off | Grant | Common Stock | 19.9k | $0.00 | $0 | | 01/19/2023 |
| 01/19/2023 | Zummo Jacqueline | Chf Scientific Operations Off | Grant | Stock Option (Right to Buy) | 119.3k | $3.02 | $360.3k | | 01/19/2023 |
| 01/10/2023 | Zummo Jacqueline | Chf Scientific Operations Off | Payment of Exercise | Common Stock | 5.2k | $3.00 | $15.7k | | 01/10/2023 |
| 01/10/2023 | Bandari Jathin | Chief Medical Officer | Payment of Exercise | Common Stock | 1.9k | $3.00 | $5.6k | | 01/10/2023 |
| 01/10/2023 | Shefferman Jesse | CEO and President | Payment of Exercise | Common Stock | 5.9k | $3.00 | $17.6k | | 01/10/2023 |
| 01/03/2023 | Zummo Jacqueline | Chf Scientific Operations Off | Payment of Exercise | Common Stock | 2.2k | $2.80 | $6k | | 01/03/2023 |
| 01/03/2023 | Fry Hannah | VP, Controller | Payment of Exercise | Common Stock | 361 | $2.80 | $1k | | 01/03/2023 |
| 01/03/2023 | Shefferman Jesse | CEO and President | Payment of Exercise | Common Stock | 6.6k | $2.80 | $18.5k | | 01/03/2023 |
| 12/30/2022 | Opaleye Management Inc. | 10% Owner | Sale | Common Stock, par value $0.001 per share | 13.2k | $2.71 | $35.7k | By Opaleye, L.P. | 12/30/2022 |
| 12/30/2022 | Opaleye Management Inc. | 10% Owner | Sale | Common Stock, par value $0.001 per share | 2.3k | $2.71 | $6.2k | By Managed Account | 12/30/2022 |
| 09/15/2022 | Opaleye Management Inc. | 10% Owner | Purchase | Common Stock, par value $0.001 per share | 5k | $3.80 | $19k | By Opaleye, L.P. | 09/14/2022 |
| 09/15/2022 | Opaleye Management Inc. | 10% Owner | Purchase | Common Stock, par value $0.001 per share | 2.3k | $3.80 | $8.7k | By Managed Account | 09/14/2022 |
| 09/14/2022 | Opaleye Management Inc. | 10% Owner | Purchase | Common Stock, par value $0.001 per share | 14.1k | $3.98 | $56.1k | By Opaleye, L.P. | 09/14/2022 |
| 09/14/2022 | Opaleye Management Inc. | 10% Owner | Purchase | Common Stock, par value $0.001 per share | 2.5k | $3.98 | $10k | By Managed Account | 09/14/2022 |
| 08/11/2022 | Shefferman Jesse | CEO and President | Purchase | Common Stock | 9.1k | $3.84 | $34.8k | | 08/11/2022 |
| 07/16/2022 | Fry Hannah | VP, Controller | Grant | Common Stock | 25k | $0.00 | $0 | | 07/16/2022 |
| 07/15/2022 | Davis Blaine | CFO | Payment of Exercise | Common Stock | 5.1k | $3.13 | $15.9k | | 07/15/2022 |
| 07/01/2022 | Bandari Jathin | Chief Medical Officer | Payment of Exercise | Common Stock | 682 | $3.22 | $2.2k | | 07/01/2022 |
| 06/30/2022 | BESHAR LUKE M | Director | Purchase | Common Stock | 10k | $3.10 | $31k | | 06/30/2022 |
| 06/08/2022 | Smith Cynthia | Director | Grant | Stock Option (Right to Buy) | 10k | $3.50 | $35k | | 06/08/2022 |
| 06/08/2022 | GARCEAU ROGER | Director | Grant | Stock Option (Right to Buy) | 10k | $3.50 | $35k | | 06/08/2022 |
| 06/08/2022 | Huang Jane | Director | Grant | Stock Option (Right to Buy) | 10k | $3.50 | $35k | | 06/08/2022 |
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