| Date | Name | Symbol | Type | Security | Shares | Price | Value | Ownership | Reported |
| 08/14/2023 | Jazz Pharmaceuticals plc | JAZZ | Sale | Ordinary Shares | 1.2k | $138.16 | $171.5k | | 08/11/2023 |
| 08/11/2023 | Jazz Pharmaceuticals plc | JAZZ | Grant | Ordinary Shares | 3.1k | $0.00 | $0 | | 08/11/2023 |
| 06/07/2023 | Cerevel Therapeutics Holdings, Inc. | CERE | Grant | Common Stock | 3.3k | $0.00 | $0 | | 06/07/2023 |
| 06/07/2023 | Cerevel Therapeutics Holdings, Inc. | CERE | Grant | Stock Option (Right to Buy) | 13.8k | $32.60 | $449.2k | | 06/07/2023 |
| 01/03/2023 | Aptinyx Inc. | APTX | Grant | Stock Option (Right to Buy) | 420k | $0.36 | $151.2k | | 01/03/2023 |
| 08/08/2022 | Jazz Pharmaceuticals plc | JAZZ | Sale | Ordinary Shares | 1.1k | $152.32 | $165.9k | | 08/05/2022 |
| 08/05/2022 | Jazz Pharmaceuticals plc | JAZZ | Exercise | Non-Qualified Stock Option (right to buy) | 8k | $55.28 | $442.2k | | 08/05/2022 |
| 08/05/2022 | Jazz Pharmaceuticals plc | JAZZ | Grant | Ordinary Shares | 2.6k | $0.00 | $0 | | 08/05/2022 |
| 08/05/2022 | Jazz Pharmaceuticals plc | JAZZ | Sale | Ordinary Shares | 8k | $155.87 | $1.2M | | 08/05/2022 |
| 06/14/2022 | Cerevel Therapeutics Holdings, Inc. | CERE | Grant | Stock Option (Right to Buy) | 23.5k | $24.35 | $571.2k | | 06/14/2022 |
| 02/07/2022 | Eton Pharmaceuticals, Inc. | ETON | Grant | Stock Option (Right to buy) | 50k | $3.78 | $189k | | 02/07/2022 |
| 01/04/2022 | Cerevel Therapeutics Holdings, Inc. | CERE | Exercise | Restricted Stock Units | 14.3k | $0.00 | $0 | | 01/04/2022 |
| 12/06/2021 | Aptinyx Inc. | APTX | Purchase | Common Stock | 100k | $2.23 | $223k | By Riedel 2020 Irrevocable Trust | 12/06/2021 |
| 12/02/2021 | Aptinyx Inc. | APTX | Grant | Stock Option (Right to Buy) | 475k | $2.28 | $1.1M | | 12/02/2021 |
| 08/06/2021 | Jazz Pharmaceuticals plc | JAZZ | Sale | Ordinary Shares | 1.3k | $147.96 | $193.2k | | 08/06/2021 |
| 07/29/2021 | Jazz Pharmaceuticals plc | JAZZ | Grant | Ordinary Shares | 2.2k | $0.00 | $0 | | 07/29/2021 |
| 06/10/2021 | Cerevel Therapeutics Holdings, Inc. | CERE | Grant | Stock Option (Right to Buy) | 58k | $13.93 | $808k | | 06/10/2021 |
| 05/17/2021 | Aptinyx Inc. | APTX | Payment of Exercise | Common Stock | 127.3k | $2.53 | $322k | | 05/17/2021 |
| 05/17/2021 | Aptinyx Inc. | APTX | Exercise | Restricted Stock Units | 380k | $0.00 | $0 | | 05/17/2021 |
| 05/17/2021 | Aptinyx Inc. | APTX | Payment of Exercise | Common Stock | 127.3k | $2.53 | $322k | | 05/17/2021 |
| 05/17/2021 | Aptinyx Inc. | APTX | Exercise | Restricted Stock Units | 380k | $0.00 | $0 | | 05/17/2021 |
| 05/03/2021 | Eton Pharmaceuticals, Inc. | ETON | Grant | Stock Option (Right to buy) | 19.7k | $8.61 | $169.2k | | 05/03/2021 |
| 02/24/2021 | Aptinyx Inc. | APTX | Grant | Stock Option (Right to Buy) | 733.3k | $3.80 | $2.8M | | 02/24/2021 |
| 01/04/2021 | Cerevel Therapeutics Holdings, Inc. | CERE | Exercise | Restricted Stock Units | 14.3k | $0.00 | $0 | | 01/04/2021 |
| 03/12/2020 | Eton Pharmaceuticals, Inc. | ETON | Grant | Stock Option (Right to buy) | 27.4k | $3.58 | $98.1k | | 03/12/2020 |
| 02/26/2020 | Aptinyx Inc. | APTX | Grant | Stock Option (Right to Buy) | 625k | $3.12 | $2M | | 02/26/2020 |
| 01/10/2020 | Aptinyx Inc. | APTX | Purchase | Common Stock | 35k | $3.00 | $105k | by Norbert G. Riedel 2015 Family Trust | 01/10/2020 |
| 08/09/2019 | Jazz Pharmaceuticals plc | JAZZ | Sale | Ordinary Shares | 726 | $135.65 | $98.5k | | 08/08/2019 |
| 08/08/2019 | Jazz Pharmaceuticals plc | JAZZ | Grant | Non-Qualified Stock Option (right to buy) | 4.8k | $137.12 | $658.9k | | 08/08/2019 |
| 08/08/2019 | Jazz Pharmaceuticals plc | JAZZ | Grant | Ordinary Shares | 1.9k | $0.00 | $0 | | 08/08/2019 |
| 05/16/2019 | Aptinyx Inc. | APTX | Grant | Restricted Stock Units | 380k | $0.00 | $0 | | 05/16/2019 |
| 02/20/2019 | Eton Pharmaceuticals, Inc. | ETON | Grant | Stock option (right to buy) | 12.5k | $7.31 | $91.4k | | 02/20/2019 |
| 01/04/2019 | Aptinyx Inc. | APTX | Grant | Stock Option (Right to Buy) | 275k | $19.33 | $5.3M | | 01/04/2019 |
| 11/15/2018 | Eton Pharmaceuticals, Inc. | ETON | Purchase | Common Stock | 5k | $6.00 | $30k | | 11/15/2018 |
| 11/12/2018 | Aptinyx Inc. | APTX | Exercise | Stock Option (Right to Buy) | 38.6k | $2.59 | $99.9k | | 11/12/2018 |
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