| Date | Name | Title | Type | Security | Shares | Price | Value | Ownership | Reported |
| 07/21/2022 | CHUNG DONG CHUNE CHRISTOPHER | Chief Medical Officer | Grant | Common Stock, $0.001 par value per share | 35.1k | $0.00 | $0 | | 07/21/2022 |
| 07/21/2022 | CHUNG DONG CHUNE CHRISTOPHER | Chief Medical Officer | Disposition | Common Stock, $0.001 par value per share | 83.4k | $33.50 | $2.8M | | 07/21/2022 |
| 07/21/2022 | CHUNG DONG CHUNE CHRISTOPHER | Chief Medical Officer | Disposition | Nonqualified Stock Option | 35.4k | $20.68 | $731.2k | | 07/21/2022 |
| 07/21/2022 | Noll Austin Francis III | Executive VP and CCO | Disposition | Non-qualified Stock Option | 72.5k | $20.68 | $1.5M | | 07/21/2022 |
| 07/21/2022 | Noll Austin Francis III | Executive VP and CCO | Disposition | Common Stock, $0.001 par value per share | 200.5k | $33.50 | $6.7M | | 07/21/2022 |
| 07/21/2022 | Noll Austin Francis III | Executive VP and CCO | Grant | Common Stock, $0.001 par value per share | 62k | $0.00 | $0 | | 07/21/2022 |
| 07/21/2022 | Davies Benjamin Drew | Executive VP and CFO | Grant | Common Stock, $0.001 par value per share | 106k | $0.00 | $0 | | 07/21/2022 |
| 07/21/2022 | Davies Benjamin Drew | Executive VP and CFO | Disposition | Common Stock, $0.001 par value per share | 181.8k | $33.50 | $6.1M | | 07/21/2022 |
| 07/21/2022 | Sullivan Thomas Joseph | President and CEO | Grant | Common Stock, $0.001 par value per share | 648.6k | $0.00 | $0 | | 07/21/2022 |
| 07/21/2022 | Sullivan Thomas Joseph | President and CEO | Disposition | Common Stock, $0.001 par value per share | 720.9k | $33.50 | $24.2M | | 07/21/2022 |
| 07/21/2022 | Daskal Ilan | Director | Disposition | Common Stock, $0.001 par value per share | 18.9k | $33.50 | $634.4k | | 07/21/2022 |
| 07/21/2022 | Guerin Eric | Director | Disposition | Common Stock, $0.001 par value per share | 10.1k | $33.50 | $338.8k | | 07/21/2022 |
| 07/21/2022 | Heine Lisa Wipperman | Director | Disposition | Common Stock, $0.001 par value per share | 26.3k | $33.50 | $880.6k | | 07/21/2022 |
| 07/21/2022 | LEVINE JOSHUA | Director | Disposition | Common Stock, $0.001 par value per share | 37.4k | $33.50 | $1.3M | | 07/21/2022 |
| 07/21/2022 | MOORE BRYANT M | Director | Disposition | Common Stock, $0.001 par value per share | 10.1k | $33.50 | $338.8k | | 07/21/2022 |
| 07/21/2022 | SCHROEDER ALICE D. | Director | Disposition | Common Stock, $0.001 par value per share | 22.4k | $33.50 | $750.6k | | 07/21/2022 |
| 06/15/2022 | Daskal Ilan | Director | Grant | Common Stock, $0.001 par value per share | 5.1k | $0.00 | $0 | | 06/15/2022 |
| 06/15/2022 | Guerin Eric | Director | Grant | Common Stock, $0.001 par value per share | 4.3k | $0.00 | $0 | | 06/15/2022 |
| 06/15/2022 | Heine Lisa Wipperman | Director | Grant | Common Stock, $0.001 par value per share | 5.1k | $0.00 | $0 | | 06/15/2022 |
| 06/15/2022 | LEVINE JOSHUA | Director | Grant | Common Stock, $0.001 par value per share | 5.1k | $0.00 | $0 | | 06/15/2022 |
| 06/15/2022 | MOORE BRYANT M | Director | Grant | Common Stock, $0.001 par value per share | 4.3k | $0.00 | $0 | | 06/15/2022 |
| 06/15/2022 | SCHROEDER ALICE D. | Director | Grant | Common Stock, $0.001 par value per share | 5.1k | $0.00 | $0 | | 06/15/2022 |
| 01/04/2022 | Davies Benjamin Drew | Executive VP and CFO | Payment of Exercise | Common Stock, $0.001 par value per share | 1.3k | $24.02 | $30k | | 01/04/2022 |
| 01/04/2022 | Noll Austin Francis III | Executive VP and CCO | Payment of Exercise | Common Stock, $0.001 par value per share | 3.7k | $24.02 | $89.1k | | 01/04/2022 |
| 01/04/2022 | CHUNG DONG CHUNE CHRISTOPHER | Chief Medical Officer | Payment of Exercise | Common Stock, $0.001 par value per share | 2.8k | $24.02 | $67.2k | | 01/04/2022 |
| 01/03/2022 | Davies Benjamin Drew | Executive VP and CFO | Grant | Common Stock, $0.001 par vale per share | 19.3k | $24.00 | $464k | | 12/31/2021 |
| 01/03/2022 | Noll Austin Francis III | Executive VP and CCO | Grant | Common Stock, $0.001 par value per share | 25.6k | $24.00 | $615k | | 12/31/2021 |
| 01/03/2022 | CHUNG DONG CHUNE CHRISTOPHER | Chief Medical Officer | Grant | Common Stock, $0.001 par value per share | 14.1k | $24.00 | $338k | | 12/31/2021 |
| 01/03/2022 | Sullivan Thomas Joseph | President and CEO | Grant | Common Stock, $0.001 par value per share | 52.1k | $24.00 | $1.3M | | 01/03/2022 |
| 01/02/2022 | CHUNG DONG CHUNE CHRISTOPHER | Chief Medical Officer | Payment of Exercise | Common Stock, $0.001 par value per share | 4k | $23.73 | $96k | | 12/31/2021 |
| 01/02/2022 | Noll Austin Francis III | Executive VP and CCO | Payment of Exercise | Common Stock, $0.001 par value per share | 4.9k | $23.73 | $116.4k | | 12/31/2021 |
| 01/02/2022 | Davies Benjamin Drew | Executive VP and CFO | Payment of Exercise | Common Stock, $0.001 par vale per share | 3.6k | $23.73 | $85.9k | | 12/31/2021 |
| 12/31/2021 | Davies Benjamin Drew | Executive VP and CFO | Grant | Common Stock, $0.001 par vale per share | 5.3k | $23.73 | $124.6k | | 12/31/2021 |
| 12/31/2021 | Davies Benjamin Drew | Executive VP and CFO | Payment of Exercise | Common Stock, $0.001 par vale per share | 2.5k | $23.73 | $59k | | 12/31/2021 |
| 12/31/2021 | Noll Austin Francis III | Executive VP and CCO | Grant | Common Stock, $0.001 par value per share | 3.7k | $23.73 | $87.2k | | 12/31/2021 |
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