| Date | Name | Title | Type | Security | Shares | Price | Value | Ownership | Reported |
| 05/23/2023 | Smiley Andrea Heslin | Director | Grant | Stock Option | 64k | $1.88 | $120.3k | | 05/23/2023 |
| 05/23/2023 | Auerbach Michael | Director | Grant | Stock Option | 64k | $1.88 | $120.3k | | 05/23/2023 |
| 05/23/2023 | JOHNSON SABRINA MARTUCCI | Director | Grant | Stock Option | 64k | $1.88 | $120.3k | | 05/23/2023 |
| 05/23/2023 | Kalali Amir H | Director | Grant | Stock Option | 64k | $1.88 | $120.3k | | 05/23/2023 |
| 05/23/2023 | Angermayer Christian | 10% Owner | Grant | Stock Option | 64k | $1.88 | $120.3k | | 05/23/2023 |
| 05/23/2023 | Camm Jason | Director | Grant | Stock Option | 64k | $1.88 | $120.3k | | 05/23/2023 |
| 03/14/2023 | Rao Srinivas | See Remarks | Grant | Stock Option | 600k | $1.18 | $708k | | 03/14/2023 |
| 03/14/2023 | Rao Srinivas | See Remarks | Grant | Restricted Stock Unit | 350k | $0.00 | $0 | | 03/14/2023 |
| 03/14/2023 | Bardin Stephen | CFO | Grant | Restricted Stock Unit | 350k | $0.00 | $0 | | 03/14/2023 |
| 03/14/2023 | Gutierrez-Esteinou Rolando | Chief Medical Officer | Grant | Stock Option | 500k | $1.18 | $590k | | 03/14/2023 |
| 03/14/2023 | Gutierrez-Esteinou Rolando | Chief Medical Officer | Grant | Restricted Stock Unit | 200k | $0.00 | $0 | | 03/14/2023 |
| 03/14/2023 | Brand Florian | See Remarks | Grant | Stock Option | 1.6M | $1.18 | $1.9M | | 03/14/2023 |
| 03/14/2023 | Brand Florian | See Remarks | Grant | Restricted Stock Unit | 700k | $0.00 | $0 | | 03/14/2023 |
| 03/14/2023 | Kirpekar Sahil | Chief Business Officer | Grant | Stock Option | 275k | $1.18 | $324.5k | | 03/14/2023 |
| 03/14/2023 | Kirpekar Sahil | Chief Business Officer | Grant | Restricted Stock Unit | 200k | $0.00 | $0 | | 03/14/2023 |
| 03/14/2023 | Bardin Stephen | CFO | Grant | Stock Option | 600k | $1.18 | $708k | | 03/14/2023 |
| 12/01/2022 | Kirpekar Sahil | Chief Business Officer | Grant | Stock Option | 750k | $3.34 | $2.5M | | 12/01/2022 |
| 05/25/2022 | Kalali Amir H | Director | Grant | Stock Option | 64k | $3.84 | $245.8k | | 05/25/2022 |
| 05/25/2022 | Angermayer Christian | 10% Owner | Grant | Stock Option | 64k | $3.84 | $245.8k | | 05/25/2022 |
| 05/25/2022 | Auerbach Michael | Director | Grant | Stock Option | 64k | $3.84 | $245.8k | | 05/25/2022 |
| 05/25/2022 | de Rosnay Alexis | Director | Grant | Stock Option | 64k | $3.84 | $245.8k | | 05/25/2022 |
| 05/25/2022 | JOHNSON SABRINA MARTUCCI | Director | Grant | Stock Option | 64k | $3.84 | $245.8k | | 05/25/2022 |
| 05/25/2022 | Smiley Andrea Heslin | Director | Grant | Stock Option | 64k | $3.84 | $245.8k | | 05/25/2022 |
| 04/29/2022 | Apeiron Investment Group Ltd. | 10% Owner | Purchase | Common Shares | 21.9k | $4.47 | $97.8k | By Apeiron Presight Capital Fund II, L.P. | 04/28/2022 |
| 04/28/2022 | Apeiron Investment Group Ltd. | 10% Owner | Purchase | Common Shares | 34.7k | $4.46 | $154.7k | By Apeiron Presight Capital Fund II, L.P. | 04/28/2022 |
| 04/25/2022 | Apeiron Investment Group Ltd. | 10% Owner | Purchase | Common Shares | 9k | $4.78 | $42.8k | By Apeiron Presight Capital Fund II, L.P. | 04/22/2022 |
| 04/22/2022 | Apeiron Investment Group Ltd. | 10% Owner | Purchase | Common Shares | 52.8k | $4.83 | $255k | By Apeiron Presight Capital Fund II, L.P. | 04/22/2022 |
| 04/21/2022 | Apeiron Investment Group Ltd. | 10% Owner | Purchase | Common Shares | 68.7k | $4.95 | $340k | By Apeiron Presight Capital Fund II, L.P. | 04/20/2022 |
| 04/20/2022 | Apeiron Investment Group Ltd. | 10% Owner | Purchase | Common Shares | 67.7k | $5.09 | $344.5k | By Apeiron Presight Capital Fund II, L.P. | 04/20/2022 |
| 04/19/2022 | Apeiron Investment Group Ltd. | 10% Owner | Purchase | Common Shares | 65.3k | $5.13 | $334.7k | By Apeiron Presight Capital Fund II, L.P. | 04/18/2022 |
| 04/18/2022 | Apeiron Investment Group Ltd. | 10% Owner | Purchase | Common Shares | 54.3k | $5.11 | $277.7k | By Apeiron Presight Capital Fund II, L.P. | 04/18/2022 |
| 04/14/2022 | Apeiron Investment Group Ltd. | 10% Owner | Purchase | Common Shares | 5k | $5.19 | $25.8k | By Apeiron Presight Capital Fund II, L.P. | 04/14/2022 |
| 04/12/2022 | Apeiron Investment Group Ltd. | 10% Owner | Purchase | Common Shares | 55.2k | $4.88 | $269.6k | By Apeiron Presight Capital Fund II, L.P. | 04/12/2022 |
| 04/11/2022 | Apeiron Investment Group Ltd. | 10% Owner | Purchase | Common Shares | 53.9k | $4.83 | $260.6k | By Apeiron Presight Capital Fund II, L.P. | 04/08/2022 |
| 04/08/2022 | Apeiron Investment Group Ltd. | 10% Owner | Purchase | Common Shares | 57.7k | $4.81 | $277.6k | By Apeiron Presight Capital Fund II, L.P. | 04/08/2022 |
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