| Date | Name | Symbol | Type | Security | Shares | Price | Value | Ownership | Reported |
| 01/03/2023 | Oyster Point Pharma, Inc. | OYST | Disposition | Stock Option (Right to Buy) | 210k | $16.00 | $3.4M | | 01/29/2022 |
| 01/03/2023 | Oyster Point Pharma, Inc. | OYST | Disposition | Stock Option (Right to Buy) | 116.5k | $18.77 | $2.2M | | 01/29/2022 |
| 01/03/2023 | Oyster Point Pharma, Inc. | OYST | Disposition | Stock Option (Right to Buy) | 211.5k | $32.65 | $6.9M | | 01/29/2022 |
| 01/03/2023 | Oyster Point Pharma, Inc. | OYST | Disposition | Stock Option (Right to Buy) | 387.2k | $5.33 | $2.1M | | 01/29/2022 |
| 01/03/2023 | Oyster Point Pharma, Inc. | OYST | Disposition | Stock Option (Right to Buy) | 434.8k | $1.02 | $443.5k | | 01/29/2022 |
| 01/03/2023 | Oyster Point Pharma, Inc. | OYST | Disposition | Stock Option (Right to Buy) | 11k | $0.20 | $2.2k | | 01/29/2022 |
| 01/03/2023 | Oyster Point Pharma, Inc. | OYST | Disposition | Performance Stock Units | 350k | $0.00 | $0 | | 01/29/2022 |
| 01/03/2023 | Oyster Point Pharma, Inc. | OYST | Disposition | Common Stock | 1000 | $0.00 | $0 | By Spouse | 01/29/2022 |
| 01/03/2023 | Oyster Point Pharma, Inc. | OYST | Disposition | Common Stock | 48k | $0.00 | $0 | | 01/29/2022 |
| 01/03/2023 | Oyster Point Pharma, Inc. | OYST | Other | Common Stock | 100.7k | $0.00 | $0 | | 01/29/2022 |
| 12/01/2022 | Oyster Point Pharma, Inc. | OYST | Payment of Exercise | Common Stock | 6.2k | $11.20 | $69.6k | | 12/01/2022 |
| 12/01/2022 | Oyster Point Pharma, Inc. | OYST | Payment of Exercise | Common Stock | 8.9k | $11.20 | $100.1k | | 12/01/2022 |
| 07/06/2022 | Oyster Point Pharma, Inc. | OYST | Grant | Performance Stock Units | 350k | $0.00 | $0 | | 07/06/2022 |
| 01/29/2022 | Oyster Point Pharma, Inc. | OYST | Payment of Exercise | Common Stock | 2.6k | $11.70 | $30.5k | | 01/29/2022 |
| 01/09/2022 | Oyster Point Pharma, Inc. | OYST | Grant | Common Stock | 46.7k | $0.00 | $0 | | 01/09/2022 |
| 01/09/2022 | Oyster Point Pharma, Inc. | OYST | Grant | Employee Stock Option (Right to Buy) | 210k | $16.00 | $3.4M | | 01/09/2022 |
| 10/21/2021 | Oyster Point Pharma, Inc. | OYST | Exercise | Employee Stock Option (Right to Buy) | 50k | $1.02 | $51k | | 10/21/2021 |
| 09/01/2021 | Oyster Point Pharma, Inc. | OYST | Exercise | Employee Stock Option (Right to Buy) | 10k | $1.02 | $10.2k | | 09/01/2021 |
| 02/19/2021 | Oyster Point Pharma, Inc. | OYST | Exercise | Employee Stock Option (Right to Buy) | 10k | $1.02 | $10.2k | | 02/19/2021 |
| 01/29/2021 | Oyster Point Pharma, Inc. | OYST | Grant | Common Stock | 25.9k | $0.00 | $0 | | 01/29/2021 |
| 01/29/2021 | Oyster Point Pharma, Inc. | OYST | Grant | Employee Stock Option (Right to Buy) | 116.5k | $18.77 | $2.2M | | 01/29/2021 |
| 07/28/2020 | Oyster Point Pharma, Inc. | OYST | Exercise | Employee Stock Option (Right to Buy) | 5k | $1.02 | $5.1k | | 07/28/2020 |
| 02/03/2020 | Oyster Point Pharma, Inc. | OYST | Grant | Employee Stock Option (Right to Buy) | 211.5k | $32.65 | $6.9M | | 02/03/2020 |
| 11/04/2019 | Oyster Point Pharma, Inc. | OYST | Purchase | Common Stock, par value $0.001 per share | 1000 | $16.00 | $16k | See footnote | 11/04/2019 |