| Date | Name | Symbol | Type | Security | Shares | Price | Value | Ownership | Reported |
| 01/04/2023 | ALPINE IMMUNE SCIENCES, INC. | NVLS | Grant | Stock Option (Right to buy) | 350k | $0.00 | $0 | | 01/04/2023 |
| 01/04/2022 | ALPINE IMMUNE SCIENCES, INC. | NVLS | Grant | Stock Option (Right to buy) | 215k | $0.00 | $0 | | 01/04/2022 |
| 09/17/2021 | ALPINE IMMUNE SCIENCES, INC. | NVLS | Sale | Common Stock | 400k | $9.40 | $3.8M | By Alpine ImmunoSciences, L.P. | 09/17/2021 |
| 09/17/2021 | ALPINE IMMUNE SCIENCES, INC. | NVLS | Sale | Common Stock | 45.3k | $10.01 | $453k | | 09/17/2021 |
| 09/16/2021 | ALPINE IMMUNE SCIENCES, INC. | NVLS | Sale | Common Stock | 6.8k | $10.00 | $67.7k | | 09/15/2021 |
| 09/15/2021 | ALPINE IMMUNE SCIENCES, INC. | NVLS | Sale | Common Stock | 3.5k | $10.00 | $34.8k | | 09/15/2021 |
| 06/28/2021 | ALPINE IMMUNE SCIENCES, INC. | NVLS | Sale | Common Stock | 3.5k | $10.00 | $34.8k | | 06/25/2021 |
| 06/25/2021 | ALPINE IMMUNE SCIENCES, INC. | NVLS | Sale | Common Stock | 9.5k | $10.01 | $94.9k | | 06/25/2021 |
| 05/20/2021 | ALPINE IMMUNE SCIENCES, INC. | NVLS | Sale | Common Stock | 1.2k | $15.00 | $18.3k | | 05/19/2021 |
| 05/19/2021 | ALPINE IMMUNE SCIENCES, INC. | NVLS | Sale | Common Stock | 51k | $15.03 | $765.9k | | 05/19/2021 |
| 05/13/2021 | ALPINE IMMUNE SCIENCES, INC. | NVLS | Sale | Common Stock | 10k | $11.52 | $115.2k | | 05/12/2021 |
| 05/12/2021 | ALPINE IMMUNE SCIENCES, INC. | NVLS | Sale | Common Stock | 10k | $11.68 | $116.8k | | 05/12/2021 |
| 04/14/2021 | ALPINE IMMUNE SCIENCES, INC. | NVLS | Sale | Common Stock | 10k | $10.52 | $105.2k | | 04/13/2021 |
| 04/13/2021 | ALPINE IMMUNE SCIENCES, INC. | NVLS | Sale | Common Stock | 10k | $10.07 | $100.7k | | 04/13/2021 |
| 03/05/2021 | ALPINE IMMUNE SCIENCES, INC. | NVLS | Sale | Common Stock | 10k | $12.99 | $129.9k | | 03/04/2021 |
| 03/04/2021 | ALPINE IMMUNE SCIENCES, INC. | NVLS | Sale | Common Stock | 10k | $13.01 | $130.1k | | 03/04/2021 |
| 02/02/2021 | ALPINE IMMUNE SCIENCES, INC. | NVLS | Sale | Common Stock | 10k | $11.74 | $117.4k | | 02/01/2021 |
| 02/01/2021 | ALPINE IMMUNE SCIENCES, INC. | NVLS | Sale | Common Stock | 3k | $12.07 | $36k | | 02/01/2021 |
| 02/01/2021 | ALPINE IMMUNE SCIENCES, INC. | NVLS | Sale | Common Stock | 7k | $13.20 | $92.7k | | 02/01/2021 |
| 01/05/2021 | ALPINE IMMUNE SCIENCES, INC. | NVLS | Grant | Stock Option (Right to buy) | 255k | $0.00 | $0 | | 01/05/2021 |
| 12/31/2020 | ALPINE IMMUNE SCIENCES, INC. | NVLS | Payment of Exercise | Common Stock | 11.1k | $12.60 | $140.1k | | 12/31/2020 |
| 12/22/2020 | ALPINE IMMUNE SCIENCES, INC. | NVLS | Other (disposition) | Common Stock | 993.8k | $0.00 | $0 | By Alpine ImmunoSciences, L.P. | 12/22/2020 |
| 12/22/2020 | ALPINE IMMUNE SCIENCES, INC. | NVLS | Other (acquisition) | Common Stock | 260.5k | $0.00 | $0 | | 12/22/2020 |
| 06/30/2020 | ALPINE IMMUNE SCIENCES, INC. | NVLS | Payment of Exercise | Common Stock | 8.2k | $9.71 | $79.9k | | 06/30/2020 |
| 01/23/2020 | ALPINE IMMUNE SCIENCES, INC. | NVLS | Grant | Common Stock | 67.6k | $0.00 | $0 | | 01/23/2020 |
| 01/23/2020 | ALPINE IMMUNE SCIENCES, INC. | NVLS | Grant | Stock Option (right to buy) | 270k | $0.00 | $0 | | 01/23/2020 |
| 12/23/2019 | ALPINE IMMUNE SCIENCES, INC. | NVLS | Gift | Common Stock | 5k | $0.00 | $0 | | 01/23/2020 |
| 12/11/2019 | ALPINE IMMUNE SCIENCES, INC. | NVLS | Gift | Common Stock | 5k | $0.00 | $0 | | 01/23/2020 |
| 02/06/2019 | ALPINE IMMUNE SCIENCES, INC. | NVLS | Grant | Stock Option (right to buy) | 200k | $0.00 | $0 | | 02/06/2019 |
| 01/18/2019 | ALPINE IMMUNE SCIENCES, INC. | NVLS | Purchase | Common Stock | 190.9k | $5.37 | $1M | Alpine ImmunoSciences, L.P. | 01/18/2019 |
| 01/18/2019 | ALPINE IMMUNE SCIENCES, INC. | NVLS | Purchase | Warrant (right to buy) | 74.4k | $12.74 | $948.4k | Alpine ImmunoSciences, L.P. | 01/18/2019 |
| 05/21/2018 | ALPINE IMMUNE SCIENCES, INC. | NVLS | Gift | Common Stock | 6k | $0.00 | $0 | | 01/18/2019 |
| 05/15/2018 | ALPINE IMMUNE SCIENCES, INC. | NVLS | Gift | Common Stock | 3k | $0.00 | $0 | | 01/18/2019 |
| 05/14/2018 | ALPINE IMMUNE SCIENCES, INC. | NVLS | Gift | Common Stock | 3k | $0.00 | $0 | | 01/18/2019 |
| 01/02/2018 | ALPINE IMMUNE SCIENCES, INC. | NVLS | Grant | Stock Option (Right to buy) | 70k | $0.00 | $0 | | 01/02/2018 |
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