| Date | Name | Symbol | Type | Security | Shares | Price | Value | Ownership | Reported |
| 08/14/2023 | Adicet Bio, Inc. | TORC | Grant | Stock Option (Right to Buy) | 26.4k | $0.00 | $0 | | 08/14/2023 |
| 08/14/2023 | Adicet Bio, Inc. | TORC | Disposition | Stock Option (Right to Buy) | 26.4k | $5.20 | $137.1k | | 08/14/2023 |
| 08/14/2023 | Adicet Bio, Inc. | TORC | Disposition | Stock Option (Right to Buy) | 18.5k | $11.49 | $212.6k | | 08/14/2023 |
| 08/14/2023 | Adicet Bio, Inc. | TORC | Grant | Stock Option (Right to Buy) | 8.2k | $0.00 | $0 | | 08/14/2023 |
| 08/14/2023 | Adicet Bio, Inc. | TORC | Disposition | Stock Option (Right to Buy) | 8.2k | $15.93 | $130.2k | | 08/14/2023 |
| 08/14/2023 | Adicet Bio, Inc. | TORC | Grant | Stock Option (Right to Buy) | 18.5k | $0.00 | $0 | | 08/14/2023 |
| 08/14/2023 | Adicet Bio, Inc. | TORC | Disposition | Stock Option (Right to Buy) | 18.5k | $15.93 | $294.7k | | 08/14/2023 |
| 08/14/2023 | Adicet Bio, Inc. | TORC | Grant | Stock Option (Right to Buy) | 28.8k | $0.00 | $0 | | 08/14/2023 |
| 08/14/2023 | Adicet Bio, Inc. | TORC | Disposition | Stock Option (Right to Buy) | 28.8k | $15.75 | $454k | | 08/14/2023 |
| 06/01/2023 | Adicet Bio, Inc. | TORC | Grant | Common Stock | 5.9k | $0.00 | $0 | | 06/01/2023 |
| 06/01/2023 | Adicet Bio, Inc. | TORC | Grant | Stock Option (Right to Buy) | 26.4k | $5.20 | $137.1k | | 06/01/2023 |
| 05/26/2023 | SOLENO THERAPEUTICS INC | SLNO | Grant | Stock option (right to buy) | 10k | $5.25 | $52.5k | | 05/25/2023 |
| 05/25/2023 | SOLENO THERAPEUTICS INC | SLNO | Grant | Stock option (right to buy) | 2.7k | $5.03 | $13.4k | | 05/25/2023 |
| 07/01/2022 | Sierra Oncology, Inc. | SRRA | Disposition | Common Stock, $0.001 par value | 1.3M | $55.00 | $72.3M | See footnotes | 07/01/2022 |
| 07/01/2022 | Sierra Oncology, Inc. | SRRA | Disposition | Stock Option (Right to Buy) | 1.5k | $13.87 | $20.8k | | 07/01/2022 |
| 07/01/2022 | Sierra Oncology, Inc. | SRRA | Disposition | Stock Option (Right to Buy) | 6.9k | $13.98 | $96.1k | | 07/01/2022 |
| 07/01/2022 | Sierra Oncology, Inc. | SRRA | Disposition | Stock Option (Right to Buy) | 6k | $18.11 | $108.7k | | 07/01/2022 |
| 07/01/2022 | Sierra Oncology, Inc. | SRRA | Disposition | Series A Warrants (Right to Buy) | 871.1k | $13.20 | $11.5M | See footnotes | 07/01/2022 |
| 06/02/2022 | Adicet Bio, Inc. | TORC | Grant | Stock Option (Right to Buy) | 18.5k | $11.49 | $212.6k | | 06/02/2022 |
| 06/01/2022 | SOLENO THERAPEUTICS INC | SLNO | Grant | Stock option (right to buy) | 2.7k | $0.00 | $0 | | 06/01/2022 |
| 03/29/2022 | SOLENO THERAPEUTICS INC | SLNO | Purchase | Common Stock | 7.7M | $0.00 | $0 | See Footnotes | 03/29/2022 |
| 03/29/2022 | SOLENO THERAPEUTICS INC | SLNO | Purchase | Warrant (right to buy) | 7.7M | $0.30 | $2.3M | See footnotes | 03/29/2022 |
| 01/31/2022 | Sierra Oncology, Inc. | SRRA | Purchase | Common Stock, $0.001 par value | 150k | $27.00 | $4M | See footnotes | 01/28/2022 |
| 01/28/2022 | Sierra Oncology, Inc. | SRRA | Exercise (in-the-money or at-the-money) | Series B Warrants (right to buy) | 287.5k | $13.20 | $3.8M | See footnotes | 01/28/2022 |
| 12/08/2021 | Adicet Bio, Inc. | TORC | Purchase | Common Stock | 500k | $14.00 | $7M | See Footnote | 12/08/2021 |
| 12/08/2021 | Adicet Bio, Inc. | TORC | Purchase | Common Stock | 500k | $14.00 | $7M | See Footnote | 12/08/2021 |
| 08/09/2021 | Verona Pharma plc | VRNA | Grant | Share Options (Right to Buy) | 64k | $0.00 | $0 | | 08/09/2021 |
| 06/08/2021 | Sierra Oncology, Inc. | SRRA | Grant | Stock Option (Right To Buy) | 6k | $18.11 | $108.7k | | 06/08/2021 |
| 06/01/2021 | SOLENO THERAPEUTICS INC | SLNO | Grant | Employee stock option (right to buy) | 31.9k | $1.02 | $32.5k | | 06/01/2021 |
| 03/02/2021 | Adicet Bio, Inc. | TORC | Grant | Stock Option (Right to Buy) | 28.8k | $15.75 | $454k | | 03/02/2021 |
| 03/02/2021 | Adicet Bio, Inc. | TORC | Grant | Stock Option (Right to Buy) | 28.8k | $15.75 | $454k | | 03/02/2021 |
| 01/08/2021 | SOLENO THERAPEUTICS INC | SLNO | Grant | Employee stock option (right to buy) | 40k | $2.24 | $89.6k | | 01/08/2021 |
| 06/26/2020 | SOLENO THERAPEUTICS INC | SLNO | Purchase | Common Stock | 3.3M | $1.65 | $5.5M | See Footnote | 06/26/2020 |
| 06/09/2020 | Sierra Oncology, Inc. | SRRA | Grant | Stock Option (right to buy | 6.9k | $13.98 | $96.1k | | 06/09/2020 |
| 05/18/2020 | SOLENO THERAPEUTICS INC | SLNO | Grant | Employee stock option (right to buy) | 9.5k | $3.41 | $32.5k | | 05/18/2020 |
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