| Date | Name | Symbol | Type | Security | Shares | Price | Value | Ownership | Reported |
| 05/17/2022 | Rockley Photonics Holdings Ltd | | Grant | Restricted Stock Unit | 65.3k | $0.00 | $0 | | 05/17/2022 |
| 05/16/2022 | Rockley Photonics Holdings Ltd | | Exercise | Restricted Stock Unit | 7.3k | $0.00 | $0 | | 05/16/2022 |
| 11/23/2021 | Rockley Photonics Holdings Ltd | | Purchase | Ordinary Share | 25k | $6.59 | $164.8k | | 11/23/2021 |
| 10/18/2021 | Rockley Photonics Holdings Ltd | | Grant | Restricted Stock Unit | 22k | $0.00 | $0 | | 10/18/2021 |
| 11/06/2020 | Cyclerion Therapeutics, Inc. | CYCN | Sale | Common Stock | 3.8k | $2.52 | $9.6k | | 11/06/2020 |
| 02/21/2020 | Cyclerion Therapeutics, Inc. | CYCN | Sale | Common Stock | 3.6k | $5.12 | $18.2k | | 02/21/2020 |
| 11/22/2019 | Cyclerion Therapeutics, Inc. | CYCN | Grant | Employee Stock Option (Right to Buy) | 75k | $2.01 | $150.8k | | 11/22/2019 |
| 11/08/2019 | Cyclerion Therapeutics, Inc. | CYCN | Sale | Common Stock | 3.9k | $2.05 | $8k | | 11/08/2019 |
| 04/01/2019 | IRONWOOD PHARMACEUTICALS INC | IRWD | Disposition | Class A Common Stock | 85.3k | $0.00 | $0 | | 04/01/2019 |
| 04/01/2019 | IRONWOOD PHARMACEUTICALS INC | IRWD | Grant | Class A Common Stock | 1.5k | $0.00 | $0 | | 04/01/2019 |
| 04/01/2019 | IRONWOOD PHARMACEUTICALS INC | IRWD | Disposition | Employee Stock Option (Right to Buy) | 232k | $0.00 | $0 | | 04/01/2019 |
| 04/01/2019 | IRONWOOD PHARMACEUTICALS INC | IRWD | Disposition | Employee Stock Option (Right to Buy) | 242.6k | $0.00 | $0 | | 04/01/2019 |
| 04/01/2019 | Cyclerion Therapeutics, Inc. | CYCN | Grant | Employee Stock Option (Right to Buy) | 222k | $0.00 | $0 | | 04/01/2019 |
| 04/01/2019 | Cyclerion Therapeutics, Inc. | CYCN | Grant | Employee Stock Option (Right to Buy) | 221.3k | $0.00 | $0 | | 04/01/2019 |
| 04/01/2019 | Cyclerion Therapeutics, Inc. | CYCN | Grant | Common Stock | 39.2k | $0.00 | $0 | | 04/01/2019 |
| 04/01/2019 | Cyclerion Therapeutics, Inc. | CYCN | Grant | Common Stock | 38.3k | $0.00 | $0 | | 04/01/2019 |
| 04/01/2019 | Cyclerion Therapeutics, Inc. | CYCN | Grant | Common Stock | 38.3k | $0.00 | $0 | | 04/01/2019 |
| 04/01/2019 | Cyclerion Therapeutics, Inc. | CYCN | Grant | Common Stock | 39.2k | $0.00 | $0 | | 04/01/2019 |
| 04/01/2019 | Cyclerion Therapeutics, Inc. | CYCN | Grant | Employee Stock Option (Right to Buy) | 221.3k | $0.00 | $0 | | 04/01/2019 |
| 04/01/2019 | Cyclerion Therapeutics, Inc. | CYCN | Grant | Employee Stock Option (Right to Buy) | 222k | $0.00 | $0 | | 04/01/2019 |
| 01/29/2019 | IRONWOOD PHARMACEUTICALS INC | IRWD | Grant | Class A Common Stock | 43.1k | $0.00 | $0 | | 01/29/2019 |
| 01/29/2019 | IRONWOOD PHARMACEUTICALS INC | IRWD | Grant | Employee Stock Option (Right to Buy) | 258.8k | $12.90 | $3.3M | | 01/29/2019 |
| 07/31/2018 | IRONWOOD PHARMACEUTICALS INC | IRWD | Grant | Class A Common Stock | 12k | $0.00 | $0 | | 07/31/2018 |
| 01/02/2018 | IRONWOOD PHARMACEUTICALS INC | IRWD | Grant | Employee Stock Option (Right to Buy) | 337.5k | $15.27 | $5.2M | | 01/02/2018 |
| 01/02/2018 | IRONWOOD PHARMACEUTICALS INC | IRWD | Grant | Class A Common Stock | 56.2k | $0.00 | $0 | | 01/02/2018 |