| Date | Name | Symbol | Type | Security | Shares | Price | Value | Ownership | Reported |
| 01/20/2023 | Zymeworks Inc. | | Purchase | Common Stock | 163.4k | $9.88 | $1.6M | See Note 1 | 01/19/2023 |
| 01/19/2023 | Zymeworks Inc. | | Purchase | Common Stock | 144.1k | $9.49 | $1.4M | See Note 1 | 01/19/2023 |
| 01/18/2023 | Zymeworks Inc. | | Purchase | Common Stock | 203k | $10.00 | $2M | See Note 1 | 01/13/2023 |
| 01/17/2023 | Zymeworks Inc. | | Purchase | Common Stock | 440k | $9.80 | $4.3M | See Note 1 | 01/13/2023 |
| 01/13/2023 | Zymeworks Inc. | | Purchase | Common Stock | 342.1k | $9.81 | $3.4M | See Note 1 | 01/13/2023 |
| 01/11/2023 | Voyager Therapeutics, Inc. | VYGR | Sale | Common Stock | 110k | $8.50 | $934.6k | See Note 1 | 01/09/2023 |
| 01/11/2023 | Zymeworks Inc. | | Purchase | Common Stock | 106.3k | $7.87 | $836.9k | See Note 1 | 01/10/2023 |
| 01/10/2023 | Zymeworks Inc. | | Purchase | Common Stock | 920k | $7.65 | $7M | See Note 1 | 01/10/2023 |
| 01/10/2023 | Voyager Therapeutics, Inc. | VYGR | Sale | Common Stock | 336.4k | $8.05 | $2.7M | See Note 1 | 01/09/2023 |
| 01/09/2023 | Voyager Therapeutics, Inc. | VYGR | Sale | Common Stock | 456k | $7.67 | $3.5M | See Note 1 | 01/09/2023 |
| 06/23/2022 | Voyager Therapeutics, Inc. | VYGR | Purchase | Common Stock | 376k | $5.66 | $2.1M | See Note 1 | 06/21/2022 |
| 06/21/2022 | Voyager Therapeutics, Inc. | VYGR | Purchase | Common Stock | 101.4k | $5.28 | $535.5k | See Note 1 | 06/21/2022 |
| 05/05/2022 | PROTHENA CORP PUBLIC LTD CO | PRTA | Purchase | Ordinary Shares | 1.1M | $29.02 | $30.8M | See Notes | 05/05/2022 |
| 05/05/2022 | PROTHENA CORP PUBLIC LTD CO | PRTA | Sale | Ordinary Shares | 1.1M | $29.02 | $30.8M | See Note | 05/05/2022 |
| 05/05/2022 | ANAPTYSBIO, INC | ANAB | Purchase | Common Stock | 668.2k | $21.63 | $14.5M | See Notes | 05/05/2022 |
| 05/05/2022 | ANAPTYSBIO, INC | ANAB | Sale | Common Stock | 668.2k | $21.63 | $14.5M | See Note | 05/05/2022 |
| 01/12/2022 | PROTHENA CORP PUBLIC LTD CO | PRTA | Purchase | Ordinary Shares | 300k | $37.50 | $11.3M | See Note 1 | 01/12/2022 |
| 12/10/2021 | Odonate Therapeutics, Inc. | ODT | Sale | Common Stock | 545k | $1.55 | $847.4k | See Note 1 | 12/01/2021 |
| 12/10/2021 | Odonate Therapeutics, Inc. | ODT | Sale | Common Stock | 5M | $1.66 | $8.3M | See Note 1 | 12/01/2021 |
| 12/09/2021 | Odonate Therapeutics, Inc. | ODT | Sale | Common Stock | 156.7k | $1.82 | $285k | See Note 1 | 12/01/2021 |
| 12/01/2021 | Odonate Therapeutics, Inc. | ODT | Sale | Common Stock | 185.9k | $1.66 | $308.7k | See Note 1 | 12/01/2021 |
| 12/01/2021 | Odonate Therapeutics, Inc. | ODT | Purchase | Common Stock | 185.9k | $1.66 | $308.7k | See Note 1 | 12/01/2021 |
| 10/01/2021 | Corvus Pharmaceuticals, Inc. | CRVS | Sale | Common Stock | 2M | $4.96 | $9.9M | See Note 2 | 09/30/2021 |
| 09/30/2021 | Corvus Pharmaceuticals, Inc. | CRVS | Sale | Common Stock | 3M | $5.04 | $15.1M | See Note 2 | 09/30/2021 |
| 06/18/2021 | PROTHENA CORP PUBLIC LTD CO | PRTA | Exercise (in-the-money or at-the-money) | Call Option (Right to Purchase) | 2.5k | $30.00 | $75k | See Note 1 | 06/18/2021 |
| 05/04/2021 | ANAPTYSBIO, INC | ANAB | Purchase | Common Stock | 165k | $23.25 | $3.8M | See Note 1 | 04/30/2021 |
| 05/03/2021 | ANAPTYSBIO, INC | ANAB | Purchase | Common Stock | 20.8k | $23.31 | $484.9k | See Note 1 | 04/30/2021 |
| 04/30/2021 | ANAPTYSBIO, INC | ANAB | Purchase | Common Stock | 35.7k | $23.16 | $826.8k | See Note 1 | 04/30/2021 |
| 03/24/2021 | PROTHENA CORP PUBLIC LTD CO | PRTA | Purchase | Ordinary Shares | 875k | $20.75 | $18.2M | See Note 1 | 03/24/2021 |
| 03/09/2021 | ANAPTYSBIO, INC | ANAB | Purchase | Common Stock | 531k | $18.70 | $9.9M | See Note 1 | 03/08/2021 |
| 03/08/2021 | ANAPTYSBIO, INC | ANAB | Purchase | Common Stock | 2.8M | $18.97 | $52.7M | See Note 1 | 03/08/2021 |
| 02/24/2021 | PROTHENA CORP PUBLIC LTD CO | PRTA | Purchase | Ordinary Shares | 10.8k | $22.02 | $237.9k | See Note 1 | 02/23/2021 |
| 02/23/2021 | ANAPTYSBIO, INC | ANAB | Purchase | Common Stock | 29.5k | $25.48 | $751.7k | See Note 1 | 02/23/2021 |
| 02/23/2021 | PROTHENA CORP PUBLIC LTD CO | PRTA | Purchase | Ordinary Shares | 44.4k | $21.05 | $934.5k | See Note 1 | 02/23/2021 |
| 02/18/2021 | PROTHENA CORP PUBLIC LTD CO | PRTA | Purchase | Ordinary Shares | 44.1k | $23.65 | $1M | See Note 1 | 02/18/2021 |
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