| Date | Name | Title | Type | Security | Shares | Price | Value | Ownership | Reported |
| 11/24/2021 | RICHO ANNA | Director | Other | Common Stock | 25k | $0.00 | $0 | | 11/24/2021 |
| 11/24/2021 | RICHO ANNA | Director | Disposition | Stock Option (Right to Buy) | 20k | $5.12 | $102.4k | | 11/24/2021 |
| 11/24/2021 | RICHO ANNA | Director | Disposition | Stock Option (Right to Buy) | 10k | $5.21 | $52.1k | | 11/24/2021 |
| 11/24/2021 | Ericson William W. | 10% Owner | Other | Common Stock | 10k | $0.00 | $0 | | 11/24/2021 |
| 11/24/2021 | Ericson William W. | 10% Owner | Other | Common Stock | 4M | $0.00 | $0 | MDV VII LP, nom for MDV VII LP, MDV VII Leaders' Fund LP, MDV ENF VII (A) LP, and MDV ENF VII (B) LP | 11/24/2021 |
| 11/24/2021 | Ericson William W. | 10% Owner | Other | Common Stock | 6k | $0.00 | $0 | MDV ENF VII (A), L.P. | 11/24/2021 |
| 11/24/2021 | Ericson William W. | 10% Owner | Other | Common Stock | 3.1k | $0.00 | $0 | MDV ENF VII (B), L.P. | 11/24/2021 |
| 11/24/2021 | Ericson William W. | 10% Owner | Other | Common Stock | 25.7k | $0.00 | $0 | MDV VII Leaders' Fund, L.P. | 11/24/2021 |
| 11/24/2021 | Ericson William W. | 10% Owner | Other | Common Stock | 288k | $0.00 | $0 | MDV IX, L.P., as nominee for MDV IX, L.P., and MDV ENF IX, L.P. | 11/24/2021 |
| 11/24/2021 | Ericson William W. | 10% Owner | Other | Common Stock | 265.2k | $0.00 | $0 | MDV VII, L.P. | 11/24/2021 |
| 11/24/2021 | Ericson William W. | 10% Owner | Disposition | Stock Option (Right to Buy) | 10k | $4.80 | $48k | | 11/24/2021 |
| 11/24/2021 | Ericson William W. | 10% Owner | Disposition | Stock Option (Right to Buy) | 10k | $2.70 | $27k | | 11/24/2021 |
| 11/24/2021 | Ericson William W. | 10% Owner | Disposition | Stock Option (Right to Buy) | 10k | $5.21 | $52.1k | | 11/24/2021 |
| 11/24/2021 | MacPhee John A | Director | Other | Common Stock | 202k | $0.00 | $0 | | 11/24/2021 |
| 11/24/2021 | MacPhee John A | Director | Disposition | Stock Option (Right to Buy) | 24k | $3.31 | $79.3k | | 11/24/2021 |
| 11/24/2021 | MacPhee John A | Director | Disposition | Stock Option (Right to Buy) | 10k | $4.80 | $48k | | 11/24/2021 |
| 11/24/2021 | MacPhee John A | Director | Disposition | Stock Option (Right to Buy) | 10k | $2.70 | $27k | | 11/24/2021 |
| 11/24/2021 | MacPhee John A | Director | Disposition | Stock Option (Right to Buy) | 10k | $5.21 | $52.1k | | 11/24/2021 |
| 11/24/2021 | DEMSKI MARTHA J | Director | Other | Common Stock | 16k | $0.00 | $0 | Martha J. Demski U/D/T 10/1/1994, Martha J. Demski Trustee | 11/24/2021 |
| 11/24/2021 | DEMSKI MARTHA J | Director | Other | Common Stock | 5k | $0.00 | $0 | | 11/24/2021 |
| 11/24/2021 | DEMSKI MARTHA J | Director | Disposition | Stock Option (Right to Buy) | 10k | $4.80 | $48k | | 11/24/2021 |
| 11/24/2021 | DEMSKI MARTHA J | Director | Disposition | Stock Option (Right to Buy) | 10k | $2.70 | $27k | | 11/24/2021 |
| 11/24/2021 | DEMSKI MARTHA J | Director | Disposition | Stock Option (Right to Buy) | 10k | $5.21 | $52.1k | | 11/24/2021 |
| 11/24/2021 | McFarlane Neil F. | CEO | Disposition | Stock Option (Right to Buy) | 200k | $1.99 | $398k | | 11/24/2021 |
| 11/24/2021 | McFarlane Neil F. | CEO | Grant | Common Stock | 75k | $0.00 | $0 | | 11/24/2021 |
| 11/24/2021 | McFarlane Neil F. | CEO | Other | Common Stock | 600k | $0.00 | $0 | | 11/24/2021 |
| 11/24/2021 | McFarlane Neil F. | CEO | Disposition | Stock Option (Right to Buy) | 250k | $6.25 | $1.6M | | 11/24/2021 |
| 11/24/2021 | MAHONEY DAVID L | Director | Other | Common Stock | 5k | $0.00 | $0 | | 11/24/2021 |
| 11/24/2021 | MAHONEY DAVID L | Director | Other | Common Stock | 112.8k | $0.00 | $0 | David L. Mahoney & Winnifred C. Ellis 1998 Family Trust | 11/24/2021 |
| 11/24/2021 | BIGHAM MICHAEL | Director | Other | Common Stock | 10k | $0.00 | $0 | | 11/24/2021 |
| 11/24/2021 | BIGHAM MICHAEL | Director | Disposition | Stock Option (Right to Buy) | 10k | $4.80 | $48k | | 11/24/2021 |
| 11/24/2021 | BIGHAM MICHAEL | Director | Disposition | Stock Option (Right to Buy) | 10k | $2.70 | $27k | | 11/24/2021 |
| 11/24/2021 | BIGHAM MICHAEL | Director | Disposition | Stock Option (Right to Buy) | 10k | $5.21 | $52.1k | | 11/24/2021 |
| 11/24/2021 | Shreedhar Vijay | Chief Commercial Officer | Grant | Common Stock | 18.8k | $0.00 | $0 | | 11/24/2021 |
| 11/24/2021 | Shreedhar Vijay | Chief Commercial Officer | Other | Common Stock | 186.8k | $0.00 | $0 | | 11/24/2021 |
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