| Date | Name | Symbol | Type | Security | Shares | Price | Value | Ownership | Reported |
| 08/23/2023 | Amylyx Pharmaceuticals, Inc. | | Exercise | Stock Option (right to buy) | 18.2k | $6.88 | $125k | | 08/23/2023 |
| 06/15/2023 | Sage Therapeutics, Inc. | SAGE | Grant | Stock Option (Right to Buy) | 10k | $56.10 | $561k | | 06/15/2023 |
| 05/16/2023 | Amylyx Pharmaceuticals, Inc. | | Sale | Common Stock | 32k | $26.93 | $861.7k | | 05/16/2023 |
| 05/16/2023 | Amylyx Pharmaceuticals, Inc. | | Sale | Common Stock | 500 | $27.60 | $13.8k | | 05/16/2023 |
| 05/16/2023 | Amylyx Pharmaceuticals, Inc. | | Exercise | Stock Option (right to buy) | 32.5k | $6.88 | $223.6k | | 05/16/2023 |
| 03/16/2023 | Amylyx Pharmaceuticals, Inc. | | Sale | Common Stock | 30.8k | $31.86 | $981.1k | | 03/16/2023 |
| 03/16/2023 | Amylyx Pharmaceuticals, Inc. | | Sale | Common Stock | 1.7k | $32.46 | $55.3k | | 03/16/2023 |
| 03/16/2023 | Amylyx Pharmaceuticals, Inc. | | Grant | Common Stock | 21.7k | $0.00 | $0 | | 03/16/2023 |
| 03/16/2023 | Amylyx Pharmaceuticals, Inc. | | Grant | Stock Option (right to buy) | 97.5k | $32.08 | $3.1M | | 03/16/2023 |
| 03/16/2023 | Amylyx Pharmaceuticals, Inc. | | Exercise | Stock Option (right to buy) | 32.5k | $6.88 | $223.6k | | 03/16/2023 |
| 03/16/2023 | Amylyx Pharmaceuticals, Inc. | | Sale | Common Stock | 30.8k | $31.86 | $981.1k | | 03/16/2023 |
| 03/16/2023 | Amylyx Pharmaceuticals, Inc. | | Sale | Common Stock | 1.7k | $32.46 | $55.3k | | 03/16/2023 |
| 03/16/2023 | Amylyx Pharmaceuticals, Inc. | | Grant | Common Stock | 21.7k | $0.00 | $0 | | 03/16/2023 |
| 03/16/2023 | Amylyx Pharmaceuticals, Inc. | | Grant | Stock Option (right to buy) | 97.5k | $32.08 | $3.1M | | 03/16/2023 |
| 01/06/2023 | Amylyx Pharmaceuticals, Inc. | | Sale | Common Stock | 1.8k | $36.08 | $66.2k | | 01/06/2023 |
| 01/06/2023 | Amylyx Pharmaceuticals, Inc. | | Sale | Common Stock | 822 | $36.79 | $30.2k | | 01/06/2023 |
| 12/30/2022 | Amylyx Pharmaceuticals, Inc. | | Exercise | Stock Option (Right to Buy) | 5k | $6.88 | $34.4k | | 12/30/2022 |
| 06/16/2022 | Sage Therapeutics, Inc. | SAGE | Grant | Stock Option (Right to Buy) | 9.9k | $31.36 | $311.9k | | 06/16/2022 |
| 02/11/2022 | Amylyx Pharmaceuticals, Inc. | | Grant | Stock Option (right to buy) | 25k | $19.63 | $490.6k | | 02/11/2022 |
| 01/06/2022 | Amylyx Pharmaceuticals, Inc. | | Grant | Common Stock | 31.7k | $0.00 | $0 | | 01/06/2022 |
| 01/06/2022 | Amylyx Pharmaceuticals, Inc. | | Grant | Stock Option (right to buy) | 142.5k | $19.00 | $2.7M | | 01/06/2022 |
| 06/16/2021 | Sage Therapeutics, Inc. | SAGE | Purchase | Common Stock | 1.8k | $55.10 | $99.7k | See Footnote 2 | 06/16/2021 |
| 06/10/2021 | Sage Therapeutics, Inc. | SAGE | Grant | Stock Option (Right to Buy) | 10k | $76.09 | $760.9k | | 06/10/2021 |
| 06/09/2020 | Sage Therapeutics, Inc. | SAGE | Grant | Stock Option (Right to Buy) | 10k | $36.47 | $364.7k | | 06/09/2020 |
| 05/14/2020 | Alkermes plc. | ALKS | Exercise | Employee Stock Option (Right to Buy) | 22k | $11.74 | $258.1k | | 05/14/2020 |
| 03/01/2020 | Alkermes plc. | ALKS | Payment of Exercise | Ordinary Shares | 1.3k | $20.84 | $27.6k | | 03/01/2020 |
| 03/01/2020 | Alkermes plc. | ALKS | Exercise | Restricted Stock Unit Award | 4.5k | $0.00 | $0 | | 03/01/2020 |
| 02/21/2020 | Alkermes plc. | ALKS | Payment of Exercise | Ordinary Shares | 1.7k | $20.24 | $34.7k | | 02/20/2020 |
| 02/21/2020 | Alkermes plc. | ALKS | Exercise | Restricted Stock Unit Award | 5.8k | $0.00 | $0 | | 02/20/2020 |
| 02/20/2020 | Alkermes plc. | ALKS | Grant | Restricted Stock Unit Award | 24.5k | $0.00 | $0 | | 02/20/2020 |
| 02/20/2020 | Alkermes plc. | ALKS | Grant | Employee Stock Option (Right to Buy) | 102.3k | $20.43 | $2.1M | | 02/20/2020 |
| 02/17/2020 | Alkermes plc. | ALKS | Payment of Exercise | Ordinary Shares | 904 | $17.77 | $16.1k | | 02/16/2020 |
| 02/17/2020 | Alkermes plc. | ALKS | Exercise | Restricted Stock Unit Award | 3k | $0.00 | $0 | | 02/16/2020 |
| 02/16/2020 | Alkermes plc. | ALKS | Exercise | Restricted Stock Unit Award | 3.4k | $0.00 | $0 | | 02/16/2020 |
| 02/16/2020 | Alkermes plc. | ALKS | Payment of Exercise | Ordinary Shares | 1.2k | $17.77 | $20.8k | | 02/16/2020 |
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