| Date | Name | Title | Type | Security | Shares | Price | Value | Ownership | Reported |
| 03/28/2019 | KOSECOFF JACQUELINE B | Director | Disposition | Ordinary Shares, 10 pence par value | 42.8k | $0.00 | $0 | See Footnote Below | 03/28/2019 |
| 03/28/2019 | KOSECOFF JACQUELINE B | Director | Disposition | Director Stock Option (right to buy) | 3.6k | $28.08 | $101.3k | | 03/28/2019 |
| 03/28/2019 | KOSECOFF JACQUELINE B | Director | Disposition | Director Stock Option (right to buy) | 3.1k | $32.34 | $101.3k | | 03/28/2019 |
| 03/28/2019 | KOSECOFF JACQUELINE B | Director | Disposition | Director Stock Option (right to buy) | 3.1k | $31.61 | $98.7k | | 03/28/2019 |
| 03/28/2019 | KOSECOFF JACQUELINE B | Director | Disposition | Director Stock Option (right to buy) | 3.2k | $32.36 | $104.1k | | 03/28/2019 |
| 03/28/2019 | KOSECOFF JACQUELINE B | Director | Disposition | Director Stock Option (right to buy) | 4.7k | $43.92 | $204.5k | | 03/28/2019 |
| 03/28/2019 | KOSECOFF JACQUELINE B | Director | Disposition | Director Stock Option (right to buy) | 4.6k | $51.53 | $236.2k | | 03/28/2019 |
| 03/28/2019 | KOSECOFF JACQUELINE B | Director | Disposition | Director Stock Option (right to buy) | 4.1k | $64.05 | $263.2k | | 03/28/2019 |
| 03/28/2019 | KOSECOFF JACQUELINE B | Director | Disposition | Director Stock Option (right to buy) | 3.8k | $71.40 | $270k | | 03/28/2019 |
| 03/28/2019 | KOSECOFF JACQUELINE B | Director | Disposition | Director Stock Option (right to buy) | 927 | $86.23 | $79.9k | | 03/28/2019 |
| 03/28/2019 | KOSECOFF JACQUELINE B | Director | Disposition | Director Stock Option (right to buy) | 436 | $114.74 | $50k | | 03/28/2019 |
| 03/28/2019 | KOSECOFF JACQUELINE B | Director | Disposition | Career Restricted Stock Units | 3.2k | $0.00 | $0 | | 03/28/2019 |
| 03/28/2019 | Shah Nirav R | Director | Disposition | Career Restricted Stock Units | 1.7k | $0.00 | $0 | | 03/28/2019 |
| 03/28/2019 | Rosebrough Walter M Jr | President & CEO | Disposition | Ordinary Shares, 10 pence par value | 48.9k | $0.00 | $0 | | 03/28/2019 |
| 03/28/2019 | Rosebrough Walter M Jr | President & CEO | Disposition | Ordinary Shares, 10 pence par value | 13k | $0.00 | $0 | See Footnote Below. | 03/28/2019 |
| 03/28/2019 | Rosebrough Walter M Jr | President & CEO | Disposition | Employee Stock Option (right to buy) | 111k | $67.98 | $7.5M | | 03/28/2019 |
| 03/28/2019 | Rosebrough Walter M Jr | President & CEO | Disposition | Employee Stock Option (right to buy) | 112.3k | $69.72 | $7.8M | | 03/28/2019 |
| 03/28/2019 | Rosebrough Walter M Jr | President & CEO | Disposition | Employee Stock Option (right to buy) | 136k | $77.07 | $10.5M | | 03/28/2019 |
| 03/28/2019 | Rosebrough Walter M Jr | President & CEO | Disposition | Employee Stock Option (right to buy) | 136.3k | $114.22 | $15.6M | | 03/28/2019 |
| 03/28/2019 | Nichol Duncan K | Director | Disposition | Career Restricted Stock Units | 5.7k | $0.00 | $0 | | 03/28/2019 |
| 03/28/2019 | Steeves Richard Martin | Director | Disposition | Ordinary Shares, 10 pence par value | 9.4k | $0.00 | $0 | | 03/28/2019 |
| 03/28/2019 | Steeves Richard Martin | Director | Disposition | Ordinary Shares,10 pence par value | 319.6k | $0.00 | $0 | See Footnote Below. | 03/28/2019 |
| 03/28/2019 | Steeves Richard Martin | Director | Disposition | Ordinary Shares,10 pence par value | 207.6k | $0.00 | $0 | See Footnote Below. | 03/28/2019 |
| 03/28/2019 | Steeves Richard Martin | Director | Disposition | Director Stock Option (right to buy) | 3.8k | $71.40 | $270k | | 03/28/2019 |
| 03/28/2019 | Steeves Richard Martin | Director | Disposition | Director Stock Option (right to buy) | 4.1k | $86.23 | $349.9k | | 03/28/2019 |
| 03/28/2019 | Steeves Richard Martin | Director | Disposition | Director Stock Option (right to buy) | 436 | $114.74 | $50k | | 03/28/2019 |
| 03/28/2019 | Steeves Richard Martin | Director | Disposition | Career Restricted Stock Units | 3.6k | $0.00 | $0 | | 03/28/2019 |
| 03/28/2019 | Coward Adrian Vincent | Sr. V P, Healthcare Spec Serv | Disposition | Ordinary Shares, 10 pence par value | 23.8k | $0.00 | $0 | | 03/28/2019 |
| 03/28/2019 | Coward Adrian Vincent | Sr. V P, Healthcare Spec Serv | Disposition | Employee Stock Option (right to buy) | 10k | $77.07 | $770.7k | | 03/28/2019 |
| 03/28/2019 | Coward Adrian Vincent | Sr. V P, Healthcare Spec Serv | Disposition | Employee Stock Option (right to buy) | 15.7k | $114.22 | $1.8M | | 03/28/2019 |
| 03/28/2019 | Carestio Daniel A | Sr VP and Chief Operating Off | Disposition | Ordinary Shares, 10 pence par value | 20.5k | $0.00 | $0 | | 03/28/2019 |
| 03/28/2019 | Carestio Daniel A | Sr VP and Chief Operating Off | Disposition | Employee Stock Option (right to buy) | 7k | $53.52 | $374.6k | | 03/28/2019 |
| 03/28/2019 | Carestio Daniel A | Sr VP and Chief Operating Off | Disposition | Employee Stock Option (right to buy) | 8k | $67.98 | $543.8k | | 03/28/2019 |
| 03/28/2019 | Carestio Daniel A | Sr VP and Chief Operating Off | Disposition | Employee Stock Option (right to buy) | 15k | $69.72 | $1M | | 03/28/2019 |
| 03/28/2019 | Carestio Daniel A | Sr VP and Chief Operating Off | Disposition | Employee Stock Option (right to buy) | 18k | $77.07 | $1.4M | | 03/28/2019 |
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