| Date | Name | Title | Type | Security | Shares | Price | Value | Ownership | Reported |
| 08/22/2023 | Farnum Rhonda | SVP, COMM & MEDICAL AFFAIRS | Sale | Ordinary Shares | 1.8k | $9.47 | $17.1k | | 08/22/2023 |
| 08/20/2023 | Grimaud Brett A. | SVP, GEN COUNSEL AND SECRETARY | Payment of Exercise | Ordinary Shares | 8.9k | $9.70 | $86.4k | | 08/20/2023 |
| 08/20/2023 | Sawaf Aziz | SVP & CFO | Payment of Exercise | Ordinary Shares | 7.1k | $9.70 | $69k | | 08/20/2023 |
| 08/20/2023 | Farnum Rhonda | SVP, COMM & MEDICAL AFFAIRS | Payment of Exercise | Ordinary Shares | 10.5k | $9.70 | $101.5k | | 08/20/2023 |
| 08/20/2023 | GRAHAM RICHARD A | SVP, RESEARCH & DEVELOPMENT | Payment of Exercise | Ordinary Shares | 10.5k | $9.70 | $101.5k | | 08/20/2023 |
| 08/20/2023 | Winningham Rick E | CEO | Payment of Exercise | Ordinary Shares | 15.8k | $9.70 | $153.3k | | 08/20/2023 |
| 08/11/2023 | GRAHAM RICHARD A | SVP, RESEARCH & DEVELOPMENT | Sale | Ordinary Shares | 2.3k | $9.99 | $23.2k | | 08/11/2023 |
| 06/14/2023 | GRAHAM RICHARD A | SVP, RESEARCH & DEVELOPMENT | Sale | Ordinary Shares | 2.3k | $10.69 | $24.8k | | 06/14/2023 |
| 06/08/2023 | Farnum Rhonda | SVP, COMM & MEDICAL AFFAIRS | Sale | Ordinary Shares | 1.8k | $11.13 | $19.9k | | 06/08/2023 |
| 05/20/2023 | Farnum Rhonda | SVP, COMM & MEDICAL AFFAIRS | Payment of Exercise | Ordinary Shares | 5.6k | $11.21 | $62.4k | | 05/20/2023 |
| 05/20/2023 | Grimaud Brett A. | SVP, GEN COUNSEL AND SECRETARY | Payment of Exercise | Ordinary Shares | 11.5k | $11.21 | $128.6k | | 05/20/2023 |
| 05/20/2023 | Sawaf Aziz | SVP & CFO | Payment of Exercise | Ordinary Shares | 8.7k | $11.21 | $98k | | 05/20/2023 |
| 05/20/2023 | GRAHAM RICHARD A | SVP, RESEARCH & DEVELOPMENT | Payment of Exercise | Ordinary Shares | 10.5k | $11.21 | $117.3k | | 05/20/2023 |
| 05/20/2023 | Winningham Rick E | CEO | Payment of Exercise | Ordinary Shares | 15.8k | $11.21 | $177.2k | | 05/20/2023 |
| 05/15/2023 | GRAHAM RICHARD A | SVP, RESEARCH & DEVELOPMENT | Sale | Ordinary Shares | 2.3k | $11.26 | $26.1k | | 05/15/2023 |
| 05/02/2023 | GRAY SUSANNAH | Director | Grant | Ordinary Shares | 9.1k | $0.00 | $0 | | 05/02/2023 |
| 05/02/2023 | GRAY SUSANNAH | Director | Grant | Share Option (Right to Buy) | 22k | $10.95 | $241.4k | | 05/02/2023 |
| 05/02/2023 | O'Connor Donal | Director | Grant | Ordinary Shares | 9.1k | $0.00 | $0 | | 05/02/2023 |
| 05/02/2023 | O'Connor Donal | Director | Grant | Share Option (Right to Buy) | 22k | $10.95 | $241.4k | | 05/02/2023 |
| 05/02/2023 | MALKIEL BURTON G | Director | Grant | Share Option (Right to Buy) | 22k | $10.95 | $241.4k | | 05/02/2023 |
| 05/02/2023 | MALKIEL BURTON G | Director | Grant | Ordinary Shares | 9.1k | $0.00 | $0 | | 05/02/2023 |
| 05/02/2023 | Smaldone Alsup Laurie | Director | Grant | Ordinary Shares | 9.1k | $0.00 | $0 | | 05/02/2023 |
| 05/02/2023 | Smaldone Alsup Laurie | Director | Grant | Share Option (Right to Buy) | 22k | $10.95 | $241.4k | | 05/02/2023 |
| 05/02/2023 | PAKIANATHAN DEEPIKA | Director | Grant | Ordinary Shares | 9.1k | $0.00 | $0 | | 05/02/2023 |
| 05/02/2023 | PAKIANATHAN DEEPIKA | Director | Grant | Share Option (Right to Buy) | 22k | $10.95 | $241.4k | | 05/02/2023 |
| 05/02/2023 | MITCHELL DEAN J | Director | Grant | Ordinary Shares | 9.1k | $0.00 | $0 | | 05/02/2023 |
| 05/02/2023 | MITCHELL DEAN J | Director | Grant | Share Option (Right to Buy) | 22k | $10.95 | $241.4k | | 05/02/2023 |
| 05/02/2023 | BROSHY ERAN | Director | Grant | Ordinary Shares | 9.1k | $0.00 | $0 | | 05/02/2023 |
| 05/02/2023 | BROSHY ERAN | Director | Grant | Share Option (Right to Buy) | 22k | $10.95 | $241.4k | | 05/02/2023 |
| 03/14/2023 | GRAHAM RICHARD A | SVP, RESEARCH & DEVELOPMENT | Sale | Ordinary Shares | 2.3k | $10.32 | $24k | | 03/14/2023 |
| 03/09/2023 | Farnum Rhonda | SVP, COMM & MEDICAL AFFAIRS | Sale | Ordinary Shares | 4k | $10.20 | $40.8k | | 03/09/2023 |
| 03/06/2023 | GRAHAM RICHARD A | SVP, RESEARCH & DEVELOPMENT | Sale | Ordinary Shares | 2.3k | $10.05 | $23.3k | | 03/06/2023 |
| 03/01/2023 | Farnum Rhonda | SVP, COMM & MEDICAL AFFAIRS | Grant | Ordinary Shares | 75k | $0.00 | $0 | | 03/01/2023 |
| 03/01/2023 | GRAHAM RICHARD A | SVP, RESEARCH & DEVELOPMENT | Grant | Ordinary Shares | 75k | $0.00 | $0 | | 03/01/2023 |
| 03/01/2023 | Sawaf Aziz | SVP & CFO | Grant | Ordinary Shares | 80k | $0.00 | $0 | | 03/01/2023 |
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