| Date | Name | Title | Type | Security | Shares | Price | Value | Ownership | Reported |
| 09/28/2021 | Markvicka Taunia | COO | Grant | Common Stock, par value $0.005 per share | 100k | $0.00 | $0 | | 09/28/2021 |
| 09/09/2021 | Verny Lea | Director | Grant | Common Stock, par value $0.005 per share | 60k | $0.00 | $0 | | 09/09/2021 |
| 09/09/2021 | Barbarick Steve K | Director | Grant | Common Stock, par value $0.005 per share | 60k | $0.00 | $0 | | 09/09/2021 |
| 09/09/2021 | SALUCK RANDY S. | Director | Grant | Common Stock, par value $0.005 per share | 60k | $0.00 | $0 | | 09/09/2021 |
| 07/27/2021 | ARONSTAM PETER | CFO | Grant | Common Stock, par value $0.005 per share | 141.4k | $0.00 | $0 | | 07/27/2021 |
| 07/27/2021 | McAvoy Cozette M. | Chief Legal Officer | Grant | Common Stock, par value $0.005 per share | 60.9k | $0.00 | $0 | | 07/27/2021 |
| 07/27/2021 | Buckheit Robert | Chief Technology Officer | Grant | Common Stock, par value $0.005 per share | 24.4k | $0.00 | $0 | | 07/27/2021 |
| 07/27/2021 | Handley Michael K | President and CEO | Grant | Common Stock, par value $0.005 per share | 296.6k | $0.00 | $0 | | 07/27/2021 |
| 07/27/2021 | Selsky Clifford | Chief Medical Officer | Grant | Common Stock, par value $0.005 per share | 101.6k | $0.00 | $0 | | 07/27/2021 |
| 07/22/2021 | Miller Langdon L | Chief Medical Officer | Exercise | Employee Stock Option (right to buy) | 10k | $3.00 | $30k | | 07/22/2021 |
| 06/19/2013 | DiCorleto Paul E | Director | Grant | Common Stock, par value $0.005 per share | 10.1k | $0.00 | $0 | | 06/19/2013 |
| 06/19/2013 | Hohn David C | Director | Grant | Common Stock, par value $0.005 per share | 10.5k | $0.00 | $0 | | 06/19/2013 |
| 06/19/2013 | BROWN JULIA R | Director | Grant | Common Stock, par value $0.005 per share | 15.9k | $0.00 | $0 | | 06/19/2013 |
| 06/19/2013 | Principi Anthony | Director | Grant | Common Stock, par value $0.005 per share | 14.5k | $0.00 | $0 | | 06/19/2013 |
| 06/14/2013 | Principi Anthony | Director | Grant | Stock Option (right to buy) | 35k | $1.58 | $55.3k | | 06/14/2013 |
| 06/14/2013 | DiCorleto Paul E | Director | Grant | Stock Option (right to buy) | 35k | $1.58 | $55.3k | | 06/14/2013 |
| 06/14/2013 | BROWN JULIA R | Director | Grant | Stock Option (right to buy) | 35k | $1.58 | $55.3k | | 06/14/2013 |
| 06/14/2013 | Antal James | Director | Grant | Stock Option (right to buy) | 35k | $1.58 | $55.3k | | 06/14/2013 |
| 06/14/2013 | Hohn David C | Director | Grant | Stock Option (right to buy) | 35k | $1.58 | $55.3k | | 06/14/2013 |
| 06/14/2013 | SALUCK RANDY S. | Director | Grant | Stock Option (right to buy) | 35k | $1.58 | $55.3k | | 06/14/2013 |
| 05/08/2013 | SALUCK RANDY S. | Director | Grant | Stock Option (right to buy) | 15k | $1.82 | $27.3k | | 05/08/2013 |
| 04/22/2013 | Principi Anthony | Director | Grant | Stock Option (right to buy) | 15k | $1.96 | $29.4k | | 04/22/2013 |
| 04/22/2013 | BROWN JULIA R | Director | Grant | Stock Option (right to buy) | 15k | $1.96 | $29.4k | | 04/22/2013 |
| 03/15/2013 | Antal James | Director | Purchase | | 3.7k | $1.56 | $5.8k | Held by Trust | 03/15/2013 |
| 11/28/2012 | Kogan Yakov | CEO | Grant | | 21.8k | $1.28 | $27.9k | By Spouse | 11/28/2012 |
| 10/25/2012 | KASTEN BERNARD L | Director | Grant | Stock Options (Right to Buy) | 100k | $1.45 | $145k | | 10/25/2012 |
| 09/21/2012 | Antal James | Director | Purchase | | 2.3k | $2.60 | $6k | | 09/21/2012 |
| 06/26/2012 | KASTEN BERNARD L | Director | Grant | | 6.3k | $0.00 | $0 | | 06/26/2012 |
| 06/26/2012 | Fonstein Michael | President | Grant | | 8.1k | $0.00 | $0 | | 06/26/2012 |
| 06/26/2012 | Lyons C Neil | CFO | Grant | | 20.3k | $0.00 | $0 | | 06/26/2012 |
| 06/26/2012 | Gudkov Andrei V | Chief Scientific Officer | Grant | | 12.8k | $0.00 | $0 | | 06/26/2012 |
| 06/26/2012 | Kogan Yakov | CEO | Grant | | 27.5k | $0.00 | $0 | | 06/26/2012 |
| 06/26/2012 | Kogan Yakov | CEO | Grant | | 15.7k | $0.00 | $0 | Held by spouse | 06/26/2012 |
| 06/26/2012 | Hohn David C | Director | Grant | | 5.6k | $0.00 | $0 | | 06/26/2012 |
| 06/15/2012 | Antal James | Director | Purchase | | 3.4k | $1.76 | $6k | | 03/16/2012 |
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