| Date | Name | Title | Type | Security | Shares | Price | Value | Ownership | Reported |
| 09/28/2023 | GILL JOHN | Director | Grant | Stock Options (option to buy) | 26.1k | $2.50 | $65.2k | | 09/28/2023 |
| 09/28/2023 | SAYARE MITCHEL | Director | Grant | Stock Options (option to buy) | 26.1k | $2.50 | $65.2k | | 09/28/2023 |
| 09/28/2023 | Drutz David | Director | Grant | Stock Options (option to buy) | 26.1k | $2.50 | $65.2k | | 09/28/2023 |
| 09/28/2023 | Jorkasky Diane | Director | Grant | Stock Options (option to buy) | 26.1k | $2.50 | $65.2k | | 09/28/2023 |
| 09/28/2023 | Hodges Philip | Director | Grant | Stock Options (option to buy) | 26.1k | $2.50 | $65.2k | | 09/28/2023 |
| 09/28/2023 | Sohn Catherine A. | Director | Grant | Stock Options (option to buy) | 26.1k | $2.50 | $65.2k | | 09/28/2023 |
| 08/15/2023 | Drutz David | Director | Purchase | Common Stock, par value $0.0001 | 300 | $2.88 | $862.5 | See Footnote | 08/15/2023 |
| 07/31/2023 | Jordt Raymond M | Chief Business Officer | Grant | Common Stock, par value $0.0001 | 1.8k | $2.81 | $5.1k | | 07/31/2023 |
| 07/31/2023 | Garg Vipin K | President and CEO | Grant | Common Stock, par value $0.0001 | 126 | $2.81 | $354.1 | | 07/31/2023 |
| 07/31/2023 | Eisenstadt Richard I | CFO | Grant | Common Stock, par value $0.0001 | 1.8k | $2.81 | $5.1k | | 07/31/2023 |
| 07/31/2023 | Harris Matthew Scott | Chief Medical Officer | Grant | Common Stock, par value $0.0001 | 691 | $2.81 | $1.9k | | 07/31/2023 |
| 07/31/2023 | Roberts M Scot | Chief Scientific Officer | Grant | Common Stock, par value $0.0001 | 568 | $2.81 | $1.6k | | 07/31/2023 |
| 03/24/2023 | Eisenstadt Richard I | CFO | Purchase | Common Stock, par value $0.0001 | 10k | $4.31 | $43.1k | | 03/24/2023 |
| 03/23/2023 | Harris Matthew Scott | Chief Medical Officer | Purchase | Common Stock, par value $0.0001 | 10k | $4.22 | $42.2k | | 03/23/2023 |
| 03/23/2023 | Sohn Catherine A. | Director | Grant | Stock Options (option to buy) | 47k | $4.19 | $196.9k | | 03/23/2023 |
| 03/23/2023 | Drutz David | Director | Purchase | Common Stock, par value $0.0001 | 9k | $4.27 | $38.4k | See Footnote | 03/23/2023 |
| 02/01/2023 | Garg Vipin K | President and CEO | Payment of Exercise | Common Stock, par value $0.0001 | 7.7k | $13.78 | $105.5k | | 01/31/2023 |
| 02/01/2023 | Garg Vipin K | President and CEO | Exercise | Restricted Stock Units | 16.5k | $0.00 | $0 | | 01/31/2023 |
| 01/31/2023 | Eisenstadt Richard I | CFO | Grant | Common Stock, par value $0.0001 | 1.2k | $10.21 | $12k | | 01/31/2023 |
| 01/31/2023 | Garg Vipin K | President and CEO | Grant | Common Stock, par value $0.0001 | 1.9k | $10.21 | $19.8k | | 01/31/2023 |
| 01/30/2023 | Garg Vipin K | President and CEO | Grant | Stock Options (option to buy) | 302.9k | $12.88 | $3.9M | | 01/30/2023 |
| 01/30/2023 | Garg Vipin K | President and CEO | Grant | Restricted Stock Units | 107.1k | $0.00 | $0 | | 01/30/2023 |
| 01/30/2023 | Harris Matthew Scott | Chief Medical Officer | Grant | Stock Options (option to buy) | 105k | $12.88 | $1.4M | | 01/30/2023 |
| 01/30/2023 | Harris Matthew Scott | Chief Medical Officer | Grant | Restricted Stock Units | 37.1k | $0.00 | $0 | | 01/30/2023 |
| 01/30/2023 | Eisenstadt Richard I | CFO | Grant | Stock Options (option to buy) | 105k | $12.88 | $1.4M | | 01/30/2023 |
| 01/30/2023 | Eisenstadt Richard I | CFO | Grant | Restricted Stock Units | 37.1k | $0.00 | $0 | | 01/30/2023 |
| 01/30/2023 | Roberts M Scot | Chief Scientific Officer | Grant | Stock Options (option to buy) | 105k | $12.88 | $1.4M | | 01/30/2023 |
| 01/30/2023 | Roberts M Scot | Chief Scientific Officer | Grant | Restricted Stock Units | 37.1k | $0.00 | $0 | | 01/30/2023 |
| 01/03/2023 | Jordt Raymond M | Chief Business Officer | Grant | Stock Options (option to buy) | 125k | $15.63 | $2M | | 01/03/2023 |
| 01/03/2023 | Jordt Raymond M | Chief Business Officer | Grant | Restricted Stock Units | 37.5k | $0.00 | $0 | | 01/03/2023 |
| 12/31/2022 | Eisenstadt Richard I | CFO | Exercise | Restricted Stock Units | 12.5k | $0.00 | $0 | | 12/31/2022 |
| 12/31/2022 | Eisenstadt Richard I | CFO | Payment of Exercise | Common Stock, par value $0.0001 | 3k | $16.45 | $49.8k | | 12/31/2022 |
| 12/22/2022 | Pisano Wayne | Director | Sale | Common Stock, par value $0.0001 | 20k | $15.01 | $300.3k | | 12/22/2022 |
| 12/22/2022 | Pisano Wayne | Director | Exercise | Stock Options (option to buy) | 20k | $2.60 | $52k | | 12/22/2022 |
| 11/30/2022 | Garg Vipin K | President and CEO | Payment of Exercise | Common Stock, par value $0.0001 | 3k | $9.95 | $29.9k | | 11/30/2022 |
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